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Asahi Kasei
Classification of scanning electron microscope images of pharmaceutical excipients using deep…
Convolutional Neural Networks (CNNs) are image analysis techniques that have been applied to image classification in various fields. In this study, we applied a CNN to classify scanning electron microscopy (SEM) images of pharmaceutical raw material powders to determine if a CNN can evaluate…
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The Effect of Cellulose Nanofibers on the Manufacturing of Mini-Tablets by Direct Powder Compression
Mini-tablets (MTs) contain a small amount of active pharmaceutical ingredients in one small tablet. MTs are advantageous because they can be fine-tuned according to the age and weight of pediatric patients and they are easy for children and the elderly to swallow. However, there are manufacturing…
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Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression
Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) was used as a model drug to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors, followed by D-optimal mixture experimental design…
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Review on Starter Pellets: Inert and Functional Cores
A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit…
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Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of…
Systemic rheumatoid arthritis treatment has been associated with numerous side effects. We attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded nanostructured lipid carriers (NLCs) that can target inflamed rheumatic joints following oral administration. In vitro evaluation…
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Incorporation of itraconazole nano-co-crystals into multiparticulate oral dosage forms
Limited research has been performed on the downstream processing of nano-co-crystal suspensions into solid oral dosage forms. The objectives of this study were to evaluate the impact of three downstream processes (wet granulation, spray granulation and bead layering) on the performance of…
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Novel preparation approach with a 2-step process for spherical particles with high drug loading and…
A novel approach for preparing drug-containing particles (DCPs) with controlled size distribution and high drug loading was developed using melt granulation. This approach comprises two steps. First, melting component adsorbed particles (MAs) were prepared by mixing and heating the melting…
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A Quality by Design (QbD) study in direct compression using highly compactible and flowing…
OBJECTIVE
CEOLUSTM UF-711 is highly compactible and flowing microcrystalline cellulose (MCC). While UF-711 has over 1.5 times the compactibility of standard grade PH-102, it has the same flow characteristics as PH-102. This is because the UF-711 particle has a round shape and has many pores inside…
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Investigation of Quantitative X-ray Microscopy for Assessment of API and Excipient Microstructure…
Assessment and understanding of changes in particle size of active pharmaceutical ingredients (API) and excipients as a function of solid dosage form processing is an important but under-investigated area that can impact drug product quality. In this study, X-ray microscopy (XRM) was investigated as…
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The effect of excipient particle size on the reduction of compactibility after roller compaction
Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of…
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