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Asahi Kasei
Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: A review
Mesoporous silica nanoparticles (MSNs) have been well-researched in the design and fabrication of advanced drug delivery systems (DDSs) due to their advantages such as good biocompatibility, large specific surface area and pore volume for drug loading, easily surface modification, adjusted size and…
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Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds
Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To…
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Solventless-mixing layering using a high shear mixer for preparing drug pellets: A feasibility study…
Our aim was to investigate the feasibility of mechanical-mixing layering using a high shear mixer, which can produce drug pellets by simply mixing drug crystals and inactive seed particles without the need for solvents or binders. Acetaminophen crystals and microcrystalline cellulose spheres were…
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Using a material database and data fusion method to accelerate the process model development of high…
High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding and controlling this complex process. In this paper, data fusion and multivariate modeling technique were applied to develop a…
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Investigating microcrystalline cellulose crystallinity using Raman spectroscopy
Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity variability can result in downstream process variability. The aim of this study was to develop models to determine…
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Asahi Kasei to build a second plant for Ceolus™ microcrystalline cellulose – Press Release
Asahi Kasei's Specialty Solutions SBU will build a second plant for microcrystalline cellulose (trade name Ceolus™) at its Mizushima Works in Kurashiki, Okayama, Japan.
Asahi Kasei currently manufactures Ceolus™, a microcrystalline cellulose used primarily in pharmaceuticals as tablet binder, in…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan…
In clinical practice, a thickening solution is frequently used to allow easy swallowing of tablets by patients suffering from dysphagia. This study investigated the effect of the thickening solution on tablet disintegration. Model tablets containing different disintegrants were prepared and their…
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Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of orlistat. Based on the in vitro results obtained in this…
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Reducing Friability of Tablets for Film Coating by Using Ceolus KG-1000
In the tablet film coating process, especially when it comes to large tablets especially with the size more than ø9mm, friability can be an issue at the early stage of the process. The purpose of the experiment was to confirm if Ceolus™ KG-1000, Asahi Kasei’s Microcrystalline Cellulose (“MCC”) with…
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