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A Review On Novel Excipients
ABSTRACT
The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of novel excipients. This review explores the types and examples…
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Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo…
Abstract
Purpose
Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal…
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Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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Preparation of core-shell controlled release tablets using direct powder extrusion 3D printing…
Three-dimensional printing (3DP) is a widely used technique to manufacture drug delivery systems due to its precision, efficiency, and tailored prescription capability. Although fused deposition modeling (FDM) is the most commonly used technique in the pharmaceutical sciences, there are several…
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Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug…
Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of…
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A Potential Breakthrough in the Enhancement of Glimepiride Solubility and Dissolution Rate by Binary…
Abstract
Purpose
Glimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type, is characterized by its low solubility and high permeability. In order to increase glimepiride’s aqueous solubility and hence increase its…
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The shelf life of ASDs: 2. Predicting the shelf life at storage conditions
Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer combination and API load in the ASD, the amorphous API might be thermodynamically metastable and crystallize over time. The…
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Polymeric micelles for cutaneous delivery of the hedgehog pathway inhibitor TAK-441: formulation…
TAK-441 is a potent inhibitor of the hedgehog pathway (IC50 4.4 nM) developed for the treatment of basal cell carcinoma that is active against the vismodegib-resistant Smoothened receptor D473H mutant. The objective of this study was to develop a micelle-based formulation of TAK-441 using…
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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression…
Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms (e.g., suitable for direct compression tableting). These…
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Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative…
Purpose
The oral administration of drugs is usually the most convenient, economical, and preferred route for patients. Chitosan is a natural polymer that is biocompatible and possesses good mucoadhesion properties and has been proposed for various biomedical applications such as scaffolds in tissue…
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