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Digital Compounding in Pharmacies: A Pilot Stability Study †
The manufacture of medicines on demand for a particular patient, at the point of care, may be achieved via 3D printing, improving therapeutic outcomes, medication adherence and patient safety. Tablets are often printed using a combination of hot-melt extrusion and fused deposition modelling. In this…
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Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the…
Malaria is a global parasitic infection that leads to substantial illness and death. The most commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but they have limitations, such as poor adherence due to frequent oral administration and gastrointestinal side effects. To…
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Advances in the Development of Amorphous Solid Dispersions: the Role of Polymeric Carriers
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level. To prepare the solid dispersions, there are many polymers with various…
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Development of extended-release formulations containing cyclobenzaprine based on physiologically…
The use of physiologically based biopharmaceutics modeling (PBBM) and bioequivalence safe space is increasingly common for immediate-release drug products. However, for extended-release (ER) formulations there are only a few examples of this application. In this study, we developed ER formulations…
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Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free…
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water-soluble drug which represents a challenge for…
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Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed…
The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or copovidone in combination with indomethacin as the active…
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An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat…
Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a similar understanding of microcrystalline cellulose (MCC) is…
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Poly vinyl pyrrolidone (PVP) based inhaled delivery carriers for olaparib for non-small cell lung…
Non-small cell lung cancer (NSCLC) is ranked first worldwide amongst deadly cancers with poor patient survival rate. While chemotherapy, radiation and surgery are available treatment options, NSCLC tumor cells are known to develop resistance and quickly metastasize. Recently, PARP inhibitors have…
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Tip loaded cyclodextrin-carvedilol complexes microarray patches
Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability and rapid first pass metabolism when administered orally. Herein, we present the development of tip microarray patches (MAPs) composed of ternary cyclodextrin (CD) complexes of carvedilol for transdermal…
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In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more…
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