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Ashland
Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug…
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Selective Laser Sintering for printing pharmaceutical dosage forms
Abstract
Three-dimensional (3D) printing has revolutionised the field of pharmaceutical manufacturing due to the unique capabilities to tailor the dosage forms properties and overcome constrains of conventional technologies. There is a plurality of 3D printing techniques that offer flexibility on…
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Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the…
Schizophrenia is a severe chronic mental illness characterised by impaired emotional and cognitive functioning. To treat this condition, antipsychotics are available in limited dosage forms, mainly oral and injectable formulations. Although injectable antipsychotics were designed to enhance…
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Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing
Semi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle size reduction technology, and it produces particles of a pure…
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Planetary roller melt granulation (PRMG) – A new continuous method for powder processing
Abstract
For the continuous operation of granulation, which is a standard unit operation in powder processing to modify the particle size, the use of twin-screw machines was established as standard method for wet and melt granulation over the last decade. A main characteristic for this technology…
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Ashland announces Polyplasdone™ Plus multifunctional disintegrant for improved pharmaceutical…
Press Release
Wilmington, Del., June 20, 2023 - Ashland is introducing Polyplasdone™ Plus, a co-processed multifunctional direct compression superdisintegrant containing a glidant and lubricant. Saving time and simplifying development, the multifunctional disintegrant offers superior powder flow…
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Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
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3D screen printing technology enables fabrication of oral drug dosage forms with freely tailorable…
3D printing offers new opportunities to customize oral dosage forms of pharmaceuticals for different patient populations, improving patient safety, care, and compliance. Although several notable 3D print technologies have been developed, such as inkjet printing, powder-based printing, selective…
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Development of a New Age-Appropriate, Chewable Tablet of Mebendazole 500 mg for Preventive…
The aim of this study was to develop an age-appropriate tablet of mebendazole 500 mg to be used in large donation programs by the World Health Organization (WHO) for preventive chemotherapy of soil-transmitted helminth (STH) infections in pre-school and school-age children living in tropical and…
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Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation…
Abstract
Objectives
Polymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential. Otherwise, a stable form of the parent drug will be recrystallized on the dissolving cocrystal surface and/or in the bulk solution during the…
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