Biogrund

XTENDED RELEASE OF ACTIVE INGREDIENTS FOR NUTRACEUTICAL & NUTRITIONAL APPLICATIONS Tylopur Xtend Nutra® is a plant derived cellulose-based ingredient produced by Shin-Etsu. It is specifically developed for nutraceutical and nutritional applications. It enables xtended release of…
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Raman spectroscopy was used as an in-line PAT tool to predict the applied coating mass of three different coating layers on caffeine cores. The different coating suspensions contained titanium dioxide in the anatase and rutile modification and iron oxide as Raman markers. Partial least…
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Here is BIOGRUNDs step-by-step guide how to prepare a suspension. Equipment & Material Equipment: propeller stirrer, beaker Material: Water, AquaPolish Here is a simple calculation for a suspension with for example 20 % solids content: AquaPolish® : 20 (%) 200g Water : 80 (%) 800g…
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Want to discover what drives the dietary supplement consumer today and in future? What does the industry has to do to satisfy the consumer needs? What does Clean Label mean for manufacturers of solid oral dosage forms? See our recording of the webcast 'Market Trends & Clean Label Solutions…
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Advantages of Hot Melt Coating (HMC) One advantage for the pharmaceutical industry is the simplification of complex dosage schemes, as several active ingredients can be combined, even those that cannot normally be combined. As the frequency of administration and complexity for users is reduced, the…
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Guidance for an excellent Hot Melt Coating Part 2 in the series of 3 articles In order to reduce the problems of other solvent-based coating processes, such as time and cost intensity, the active ingredient coating by means of Hot Melt Coating (HMC) was developed. HMC is a process in which…
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Disadvantages of solvent-based coatings and why alternatives are needed The coating of active substances requires the suspension of the auxiliary substances in a solvent. This mixture is then applied to the active ingredient particles. If water is involved, drying is required. This process is…
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Many parameters must be considered before and during the pharmaceutical coating process. Sometimes it is necessary to adjust parameters to get the best possible result. The correct and precise choice of process parameters is crucial for a flawless result and an optimal coating. Various influencing…
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Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from…
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Mesalazine is widely used drug compound to treat inflammations within the gastrointestinal tract (GIT). The APIs is mostly supplied as very fine powder with extremely poor flowability and wet granulation is most often used to meet the challenge. However, mesalazine is prone to degradation by several…
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