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Budenheim
Using AI/ML to predict blending performance and process sensitivity for Continuous Direct…
Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the prediction of fill level in inclined linear blenders at steady state by mapping a wide range of bulk powder characteristics to processing parameters. Predicting fill levels enables the calculation of…
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PVA as binder in continuous twin-screw granulation
Introduction
Granulation of powder blends is a commonly applied technique for pharmaceutical formulations which have no suitable flowability or compactability or are inhomogeneous with regards to the API content. Mainly wet granulation is applied3 and here, especially continuous twin-screw…
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Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused…
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial…
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CPHI Barcelona 2023 – with a focus on excipients
This year CPHI Europe opens its doors in Barcelona at Fira Barcelona Gran Via.
From 24th to 26th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack,
P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
Pharma Excipients gives you an…
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Electrospun metal–organic frameworks-loaded nanofibrous carriers for drug delivery systems
Nanotechnology-based-drug-delivery processes are widely applicable for specific drug release. Various pharmaceutical carriers, such as polymeric nano-carriers (solid lipid nanoparticles, micelles, nano-gels/hydrogels, dendrimers, polymeric nano-shapes), vesicular carriers (liposome, noisome),…
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Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible…
Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated. In the present study, pancreatin was employed as a model enzyme mixture, which was formulated in tablet…
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Simulation of roller compaction by combination of a compaction simulator and oscillating mill – A…
This study investigates the feasibility of a compaction simulator and oscillating mill to mimic a roller compactor as a material sparing approach for process development. Microcrystalline cellulose and dicalcium phosphate dihydrate were selected to represent soft and hard materials, respectively.…
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The impact of material chemistry and morphology on attrition behavior of excipients during high…
Particle breakage by attrition is unavoidable in some unit operations and can lead to uncontrolled behavior of materials during processing. The aim of this study is to clarify the impact of material properties on attrition behavior. For the first time, an integral study with varying morphologies and…
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Comparative Study of Selected Excipients’ Influence on Carvedilol Release from Hypromellose Matrix…
Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from HPMC-based matrix tablets was studied. A…
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Influence of compression kinetics during tableting of fluidized bed-granulated microorganisms on…
As tablets are convenient to administer to patients, ensure safe dosing and allow cost-effective production on a large scale, they are the favored dosage form for numerous active pharmaceutical ingredients but also for the administration of viable probiotic microorganisms. Granules with viable yeast…
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