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Budenheim
Performance comparison of PLA- and PLGA-coated porous bioceramic scaffolds: Mechanical,…
Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are a principal group of biomaterials employed for the regeneration of damaged tissues and therapeutic delivery. The development of ceramic tissue engineering scaffolds with an appropriate combination of…
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Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those…
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Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous…
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non-conforming material from the finished product. These…
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Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw…
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Review on Starter Pellets: Inert and Functional Cores
A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit…
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Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with…
Reliable and stable tablet formulations for rosuvastatin calcium in four strengths: 5 mg, 10 mg, 20 mg and 40 mg have been developed. Rosuvastatin is a cholesterol-lowering statin drug and is known to be unstable during storage. The possibility of its stabilization with inorganic salts of…
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Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on…
The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures (CPs) from 50 to 500 MPa was performed using a compaction…
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Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis…
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring development of highly aggressive squamous cell carcinomas.…
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Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique
Pharmaceutical tablets can be produced on different kinds of presses that may have very different compaction kinematics. Strain rate sensitivity (SRS) is thus an important property for the powders used to produce pharmaceutical tablets. Viscoelasticity is one of the aspects of the SRS and can be…
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