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Budenheim
Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel…
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on the inert cores made of microcrystalline…
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Characterization of a Novel Drying Technology for Continuous Processing of Cohesive Materials: An…
This work addresses the influence of several process parameters on the performance of a novel drying device (patent NL2020740B1). In the new dryer, the processed substance is conveyed through the grooves of a large rotor via an interlocking screw design. A gentle, forced flow is created, preventing…
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Evaluating mechanical properties and tabletability of pharmaceutical powders with a novel…
Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long term.
Tablet is still the most commonly used pharmaceutical…
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Spray Drying for Direct Compression of Pharmaceuticals
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses.…
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A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
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A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
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Towards better understanding of the influence of process parameters in roll compaction/ dry…
A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If the product is to be manufactured continuously, it can be of interest to monitor the hardness of the material at different stages of manufacturing. Using the controlled process…
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Effect of intra- and extragranular addition of highly porous tribasic calcium phosphate on…
Immediate release, compositionally proportional formulations of acyclovir comprising porous tribasic calcium phosphate were developed and compared with commercial tablets. Comparison of the dissolution behavior was carried out using a compendial method, as well as with the help of a biorelevant…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Melt Granulation: a Comparison of Granules produced via High-shear Mixing and Twin-screw Granulation
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation…
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