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Captisol
Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and…
Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare the inclusion complex using β-Cyclodextrins (β-CDs) as complexing agent and D -α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as ternary substance to…
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A synthetic antibiotic class overcoming bacterial multidrug resistance
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural products (semisynthesis), a method ill-equipped to…
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Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
Microphysiological in vitro systems are platforms for preclinical evaluation of drug effects and significant advances have been made in recent years. However, existing microfluidic devices are not yet able to deliver compounds to cell models in a way that reproduces the real physiological drug…
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Development of Chitosan/Cyclodextrin Nanospheres for Levofloxacin Ocular Delivery
Levofloxacin (LVF) is an antibacterial drug approved for the treatment of ocular infections. However, due to the low ocular bioavailability, high doses are needed, causing bacterial resistance. Polymeric nanospheres (NPs) loading antibiotic drugs represent the most promising approach to eradicate…
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Enhancing in vitro cytotoxicity of doxorubicin against MCF-7 breast cancer cells in the presence of…
This study was aimed to evaluate the impact of water-soluble β-cyclodextrin polymer (β-CDP), as a nanocarrier, on the therapeutic efficacy of the commercial doxorubicin (DOX). The β-CDP was synthesized by cross-linking of β-CD using epichlorohydrin. The chemical structure of the cross-linked β-CDP…
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Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model…
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films. Most drugs are bitter and increased solubility may correlate…
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Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide)…
Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from β-cyclodextrin (β-CD) based polymers.
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Ligand’s Captisol Technology Plays Key Role In The Manufacture Of Gilead’s Veklury, The…
SAN DIEGO--(BUSINESS WIRE) -- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) today highlighted the company’s role in the manufacturing of Veklury® (remdesivir), Gilead Sciences’ antiviral drug for the treatment of patients with COVID-19 requiring hospitalization. Veklury is formulated with…
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Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for Emergency Use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). TFF produces brittle matrix nanostructured aggregates that are sheared into…
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