Captisol

Highlights • 1:1 solid inclusion complex (IC) of chrysin with β-cyclodextrin prepared. • Microwave irradiation method is time-saving and environmentally benign. • Microwaved IC has highest drug content, solubility and hemocompatibility. • Microwaved IC displayed superior…
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Cannabis has been used in pain management since 2900 BC. In the 20th century, synthetic cannabinoids began to emerge, thus opening the way for improved efficacy. The search for new forms of synthetic cannabinoids continues and, as such, the aim of this review is to provide a comprehensive tool for…
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Article by Omar Sacirbay - mjbizmagazine As an emergency room physician and the founding CEO of Vireo Health, a multistate marijuana company based in Minnesota, Kyle Kingsley had thought extensively about how cannabinoids could replace opioids for pain relief. So, in 2015, when Vireo’s…
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Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous fibers (Cooley, 1899). Beginning from the 1980s and particularly during the recent decade, the technology has gained increasing attention. Possibly this can be…
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Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting fatty acids and cholesterol, which implies that they are not…
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Age-related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years. Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor (VEGF) plays a causal role in the formation of CNV. Although…
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Dutasteride is prescribed as a once daily oral capsule for the treatment of symptomatic benign prostatic hyperplasia. As an alternative and patient focused drug product, this laboratory evaluated the potential to deliver dutasteride in a controlled/sustained manner when formulated as a…
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Tamoxifen (TMX), a class II antiestrogen drug consistent with the biopharmaceutical classification system, shows low plasma levels leading to therapeutic failure as a result of poor aqueous solubility. Complexation with multifunctional excipients cyclodextrins (CDs) is an effective technique to…
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Ligand Pharmaceuticals Incorporated presented positive results from a Phase 1 clinical trial of its Captisol-enabled (CE) Iohexol program at ASN Kidney Week 2019 in Washington, D.C. The CE-Iohexol program was established in January 2018 to develop a Captisol-enabled, next-generation contrast…
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The aim of present study was to explore the impact of Atorvastatin (ATR) Sulfobutylether beta-cyclodextrin complex (ATR-SBE-β-CD) on ATR dissolution behavior. Various batches of inclusion complexes were formulated using various drug: polymer ratios (1:1, 1:3, and 1:5); using β-CD and SBE-β-CD and…
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