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Comparison of Proprietary and 3 Generic Formulation of Propofol for Induction of General Anesthesia
Background: This study compared the properties of propofol bolus for induction of general anesthesia between proprietary and 3 generic formulations, to assess if solvent differences had clinically relevant consequences on efficacy or side effects. Many studies have investigated different…
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CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3…
Prexasertib (LY2606368) is a potent and selective small molecule inhibitor of cell-cycle checkpoint CHK1 and CHK2 protein kinases and is currently under clinical evaluation for treatment of pediatric malignancies.
As a candidate therapy for pediatric Group 3 medulloblastoma (G3MB), prexasertib…
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Preclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3…
Background
Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investigated Akt/mTOR pathway activation and the preclinical efficacy of dual…
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