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Croda
Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug formulation and wound dressing taking into consideration clinical…
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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of…
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with…
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Predictions of biorelevant solubility change during dispersion and digestion of lipid-based…
Abstract
Computational approaches are increasingly explored in development of drug products, including the development of lipid-based formulations (LBFs), to assess their feasibility for achieving adequate oral absorption at an early stage. This study investigated the use of computational…
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Development of emulgel formulation from Markhamia tomentosa leaf extract: Characterization and in…
Abstract
Objectives:
Skin infections are mild to severe infections often treated with antimicrobial agents. There is an increase in resistance to antimicrobial agents necessitating the search for new medicines. This study developed an emulgel formulation of Markhamia tomentosa leaf extract and…
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Self-Nano-Emulsifying Drug-Delivery Systems: A Limelight on the Development, Advancements and…
Abstract
Back ground: Orally administered medication solubility is a key concern for the pharmaceutical business; about 35-40% of newly introduced pharmaceuticals have less aqueous solubility, resulting in deprived dissolution and limited bio-availability. Employment of lipid-oriented drug release…
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In Vitro Predictive Model for Intestinal Lymphatic Uptake: Exploration of Additional Enhancers and…
Abstract
Drug absorption via chylomicrons holds significant implications for both pharmacokinetics and pharmacodynamics. However, a mechanistic understanding of predicting in vivo intestinal lymphatic uptake remains largely unexplored. This study aimed to delve into the intestinal lymphatic uptake…
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Design of Experiment (DoE) Approach for Developing Inhalable PLGA Microparticles Loaded with…
Abstract
Tuberculosis (TB) is an airborne bacterial infection caused by Mycobacterium tuberculosis (M. tb), resulting in approximately 1.3 million deaths in 2022 worldwide. Oral therapy with anti-TB drugs often fails to achieve therapeutic concentrations at the primary infection site (lungs). In…
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Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease
Abstract
Purpose
This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy.
Methods
Tween® 80 and Soluplus® were evaluated to enhance the water solubility of IVM powder. Three dissolving MAPs were fabricated using…
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Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and…
Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuroprotective effects in various CNS disorders, including epilepsy. Due to rapid elimination and poor bioavailability, treatment with APO is challenging. Correspondingly, novel…
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Novel nano-in-micro fabrication technique of diclofenac nanoparticles loaded microneedle patches for…
Abstract
Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly prescribed for managing osteoarthritis, rheumatoid arthritis, and post-surgical pain. However, oral administration of diclofenac often leads to adverse effects. This study introduces an innovative nano-in-micro approach to…
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