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Croda
Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and…
Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products…
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Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight…
Abstract
Aim
The aim of this study was the development and in vivo evaluation of different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH).
Methods
Nanoemulsions (NE) were developed consisting of mainly non-digestible components and variations of polyglycerol-,…
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Self-emulsifying drug delivery systems: A versatile approach to enhance the oral delivery of BCS…
Biopharmaceutical classification systems (BCS) class III drugs belongs to a group of drugs with high solubility in gastrointestinal (GI) fluids and low membrane permeability result in significantly low bioavailability. Self-emulsifying drug delivery systems (SEDDS) considered a suitable candidate to…
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Effect of cyclosporine A – Tempol topical gel for the treatment of alopecia and…
Over the years, extensive research has been carried out to develop new chemical entities for hair loss treatment. Despite these efforts, the newly developed topical and oral treatments have not proven to be curative. Hair loss can result from underlying mechanisms, such as inflammation and apoptosis…
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Solid implantable devices for sustained drug delivery
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay…
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Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an…
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression. Research on the solubility of medications in different oils, surfactants, co-surfactants, and solvents has been…
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A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma
Abstract
Melanoma is the most aggressive form of skin cancer, with increasing incidence and mortality rates. To overcome current treatment limitations, a hybrid molecule (HM) combining a triazene and a sulfur L-tyrosine analogue, was recently synthesized, incorporated in long blood circulating…
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Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination…
Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs…
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Croda Breaks Ground On New Manufacturing Facility For Pharmaceutical Excipients In Lamar,…
(CLINTON COUNTY, PA) – Croda, Inc., the company that uses smart science to create high-performance ingredients and solutions that improve lives, broke ground on 9 May 2023, its newest manufacturing facility in Lamar, Clinton County, Pennsylvania.
In line with Croda Pharma’s strategy to “Empower…
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A systematic review of commercial high concentration antibody drug products approved in the US:…
Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique advantage of allowing subcutaneous…
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