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Croda
Eudragit® FS Microparticles Containing Bacteriophages, Prepared by Spray-Drying for Oral…
Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
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Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational…
ABSTRACT
Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the…
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Development and evaluation of niacinamide transdermal formulation by artificial membrane…
Despite many efforts to improve the transdermal permeability of drugs, most of them are blocked by the skin barrier. Niacinamide (NAC) is a Biopharmaceutics Classification System class I drug with high aqueous solubility and intestinal permeability. Due to the high solubility and intestinal…
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Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release
The non-steroid anti-inflammatory drug ketoprofen (KP) as a model molecule is encapsulated in different poly(lactide-co-glycolide) (PLGA) nanostructured particles, using Tween20 (TWEEN) and Pluronic F127 (PLUR) as stabilizers to demonstrate the design of a biocompatible colloidal carrier particles…
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Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of…
In spite of recent progress made in the field of peptide and protein delivery, oral administration of insulin and similar drugs remains a challenge. In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to…
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The future of mRNA delivery: Advancements in engineering lipid nanoparticles for enhanced…
Messenger RNA (mRNA) has played a crucial role in recent vaccine developments and is at the forefront of much current medical research. Traditionally. the delivery of mRNA systemically via lipid nanoparticles (LNPs) innately results in LNP accumulation in the liver limiting the access to other…
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Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral…
This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing surfactant-based amorphous solid dispersions using resveratrol (RES) as a model drug. After preliminary screening of…
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Croda announces two new partnerships to drive sustainable delivery systems for the pharmaceutical…
PRESS RELEASE
19 May 2023:
Croda International Plc (Croda) today announced that it has signed two new partnership agreements that will help the pharmaceutical industry move towards a more sustainable supply chain for vaccine adjuvants.
The first partnership is an exclusive license agreement…
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3D printing of microencapsulated Lactobacillus rhamnosus for oral delivery
3D Printing is an innovative technology within the pharma and food industries that allows the design and manufacturing of novel delivery systems. Orally safe delivery of probiotics to the gastrointestinal tract faces several challenges regarding bacterial viability, in addition to comply with…
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3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms:…
3D printing technology in medicine is gaining great attention from researchers since the FDA approved the first 3D-printed tablet (Spritam®) on the market. This technique permits the fabrication of various types of dosage forms with different geometries and designs. Its feasibility in the design of…
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