Croda

Nicardipine hydrochloride is an anti-hypertensive drug that is used off-label to treat hypertension in children. A previous oral formulation of nicardipine hydrochloride was developed using a commercial vehicle as an excipient. However, ready-to-use vehicles are prone to supply shortages, and their…
Read More...

Discover the Benefits of Super Refined Excipients Polyethylene glycols (PEGs) are excipients that are widely used in oral, parenteral and topical delivery dosage forms. Low molecular weight PEGs, such as PEG 300 and PEG 400 in particular, are used as solvents in concentrated formulations that are…
Read More...

Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable…
Read More...

The current investigation aimed to develop a barberine (BRN) loaded liquidsolid compact (SLC) to improve the oral therapeutic effectiveness of BRN. full factorial design was employed and the effect of the carrier:coating ratio (X1) and neusilin :corn starch ratio (X2) was systematically investigated…
Read More...

Pazopanib is the first-line treatment for patients with advanced or metastatic renal cell carcinoma. However, the commercially available preparation is characterized by low solubility, poor bioavailability and suboptimal therapeutic concentrations in majority of patients. The aim of this study was…
Read More...

Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major…
Read More...

Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design were employed in design. Globule size, TEM, DSC, and SEM studies…
Read More...

Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral administration associated with many GIT, hepatic and renal problems.…
Read More...

Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a…
Read More...

The importance of excipients Formulation development has been emphasized greatly in recent years, whether that be for targeting delivery of the drug, aesthetics of the final formulation, or shelf life of the final drug product. Some excipients play a simple role in drug formulations while others…
Read More...