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Croda
The Power of Excipient Purity in API Stability – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Active Pharmaceutical Ingredient (API) stability is one of the most important factors in pharmaceutical formulation development. Degradation and instability are common problems that can lead to extended development timescales, additional…
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Innovative lipids for Your Nucleic Acid Delivery research
The history and evolution of Nucleic Acid Delivery systems
mRNA and liposomes were both first discovered in the 1960s, and liposomes were used to deliver mRNA into eukaryotic cells in 1978.1,2 Even with the ability to inject mRNA into cells, there were several technical challenges to overcome…
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Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery
Abstract
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated…
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Effect of Penetration Enhancers on Transdermal Delivery of Oxcarbazepine, an Antiepileptic Drug…
Oxcarbazepine (OXC) is an anticonvulsant drug, indicated for the treatment of the neurological disorder, epilepsy. The objective of the present study was to evaluate the transdermal delivery of OXC from microemulsions using different penetration enhancers. Transcutol® P (TRC), oleic acid (OA),…
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Design Development and Evaluation of Nanostructured Lipid Carrier Loaded Emulgel of Voriconazole
Voriconazole is a second generation triazole derived from fluconazole. Voriconazole is used for the treatment of various fungal infections. Though it has excellent antifungal activity, there are several side effects associated with it. In order to overcome these limitations, nanostructures may be an…
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Green Nanoemulsion Water/Ethanol/Transcutol/LabM-Based Treatment of Pharmaceutical Antibiotic…
Contaminated wastewater released from hospital, domestic, and industrial sources is a major challenge to aquatic animals and human health. In this study, we addressed removal of erythromycin (ERN) from contaminated water employing water/ethanol/Transcutol/Labrafil M 1944 CS (LabM) green…
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Encapsulation of cannabidiol in oil-in-water nanoemulsions and nanoemulsion-filled hydrogels: a…
Abstract
Hypothesis
Lipophilic cannabidiol can be solubilized in oil-in water nanoemulsions, which can then be impregnated into chitosan hydrogels forming another colloidal system that will facilitate cannabidioil's release. The delivery from both systems was compared, alongside structural and…
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Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization
Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension (PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted delivery to the lungs through nebulization was proposed as an alternative approach. This poorly soluble drug was…
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End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for…
A survey performed by the AAPS Drug Product Handling community revealed a general, mostly consensus, approach to the strategy for the selection of surfactant type and level for biopharmaceutical products. Discussing and building on the survey results, this article describes the common approach for…
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Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and…
The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to…
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