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Croda
Development and Characterization of Celecoxib Solid Self-nanoemulsifying Drug Delivery Systems…
Self-nanoemulsifying drug delivery systems (SNEDDS) represent an interesting platform for improving the oral bioavailability of poorly soluble lipophilic drugs. While Liquid-SNEDDS (L-SNEDDS) effectively solubilize the drug in vivo, they have several drawbacks, including poor storage stability.…
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Novel Bos indicus Fat-Based Nanoparticulate Lipospheres of Miconazole Nitrate as Enhanced…
Nanoparticulate lipospheres of miconazole nitrate were formulated and incorporated into mucoadhesive gels for enhanced treatment of oral candidiasis. Extracted cow fat and Phospholipon® 90H (7:3) were used to prepare a lipid matrix by fusion. Nanoparticulate lipospheres with drug concentrations (0,…
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PEGylated SLN as a Promising Approach for Lymphatic Delivery of Gefitinib to Lung Cancer
Purpose: The present study aimed to develop gefitinib-loaded solid lipid nanoparticles (GEF-SLN), and GEF-loaded PEGylated SLN (GEF-P-SLN) for targeting metastatic lung cancer through the lymphatic system.
Methods: The prepared SLNs were characterized in terms of physicochemical properties,…
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Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation…
The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The…
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Preparation and Characterization of Clopidogrel Bisulfate-Hydroxypropyl-β-Cyclodextrin Mixed…
The study aimed to increase the intestinal solubility and absorption of orally bioavailable clopidogrel-bisulfate (CPB) by complexing with hydroxypropyl-β-cyclodextrin (HCD) to form a binary inclusion complex that was stabilized by Tween 80 (T80) resulting into mixed inclusion complex. The results…
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Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan…
Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a biopharmaceutics classification system (BCS) class III medication with an absolute oral bioavailability of less than 40%. As a…
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Formulation of Plumbagin Loaded Microemulsion: Evaluation of Anti-rheumatoid efficacy in Wistar Rat…
Rheumatoid arthritis has become a common disease among the elderly. Plumbagin, a plant-derived chemical, has been shown to lower the levels of proinflammatory cytokines and interleukins linked to rheumatoid arthritis progression. The objective of the present research work was to assess the…
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In vivo and in vitro per se effect evaluation of Polycaprolactone and Eudragit® RS100-based…
Biodegradable polymeric nanocapsules (NC) present incredible characteristics as drug nanocarriers that optimize drug targeting. However, However, a more detailed isolated effect of polymer-based nanoparticles as drug carriers is required. This work aimed to evaluate the per se effect of blank-NC…
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Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of…
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A…
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Nanoemulsion for delivery of anticancer drugs
Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark. This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells andrapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxicanticancer agents. As an…
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