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Croda
Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil…
Abstract
Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by…
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Formulation and Evaluation of Transdermal Gel Containing Tacrolimus-Loaded Spanlastics: In Vitro, Ex…
Our goal was to prepare Span 60-based elastic nanovesicles (spanlastics (SPLs)) of tacrolimus (TCR) using the adapted ethanol injection method, characterize them, and evaluate their ability to improve the transdermal permeation of the active substance. The impact of two different concentrations of…
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3D Printed Praziquantel Formulations via Direct Powder Extrusion for the Treatment of…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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UK Government to support expansion of Croda’s lipid systems manufacturing facility
Croda International Plc that uses smart science to create high performance ingredients and solutions that improve lives, announces that it has been awarded a £15.9 million grant by the UK Government to expand its manufacturing facility in Leek, Staffordshire. The investment will significantly…
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Optimization of the Conditions of Solid Lipid Nanoparticles (SLN) Synthesis
Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems. They are classified as solid lipid nanocarriers that can successfully carry both hydrophilic and hydrophobic drugs. SLNs are based on a biocompatible lipid matrix that is enzymatically degraded into natural…
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Phase separation in surfactant-containing amorphous solid dispersions – orthogonal analytical…
Amorphous-amorphous phase separation (AAPS) is an important phase transition process for amorphous solid dispersion (ASD) performance both in terms of drug release as well as physical and chemical stability during storage. Addition of surfactants to ASDs systems can impact both of these processes.…
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Exclusive license for Croda to commercialise SSI’s CAF® vaccine adjuvants
March 3, 2022
Exclusive license for Croda to commercialise SSI’s CAF® vaccine adjuvants
Croda International Plc, which uses smart science to improve lives, announces today that it has entered a strategic collaboration with Statens Serum Institut (“SSI”), the leading Danish Governmental…
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Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system
The purpose of the present study was to prepare and evaluate self-emulsifying drug delivery system (SEDDS) of curcumin (Cur) to enhance its solubility and percentage release for the evaluation of anti-inflammatory effect. Curcumin loaded SEDDS formulation was prepared, and zones of…
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A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
A properly designed nanosystem aims to deliver an optimized concentration of the active pharmaceutical ingredient (API) at the site of action, resulting in a therapeutic response with reduced adverse effects. Due to the vast availability of lipids and surfactants, producing stable lipid dispersions…
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Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein…
Polysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could lead to particle formation and instability of the drug formulation. We investigated how the fatty acid composition of polysorbate 80 impacts the degradation…
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