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Croda
Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance. One promising strategy to formulate such dosage forms is the incorporation of microparticles into a bio-adhesive gel. The main aim…
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Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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Potentially Harmful Excipients in Neonatal Medications: An Observational and Cross-Regional…
Objectives: We aimed to examine the administration of eight potentially harmful excipients of interest (EOI), including paraben, polysorbate 80, propylene glycol, benzoate, saccharin sodium, sorbitol, ethanol, and benzalkonium chloride, to hospitalized neonates in Japan and to compare the frequency…
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Anaphylaxis and the inclusion of polysorbates in biotherapeutics
20. December 2017
The formulation and manufacturing of parenteral biotherapeutic products occur at the interface of science and regulatory concerns. Science dictates the formulation composition, often including the addition of certain excipients in order to stabilize the …
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Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan
11. December 2017
Abstract
In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg),…
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A retrospective and observational analysis of harmful excipients in medicines for hospitalised…
13. March 2017
Background Medicines used in neonates contain different excipients, which may not be safe in this age group.
Objective To analyse the frequency at which hospitalised neonates are exposed to harmful excipients (HEs) and to identify substitution possibilities for…
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Effect of Different Meltable Binders on the Disintegration and Dissolution Behavior of Zolmitriptan…
22. February 2017
Abstract
Objective: Fast melt tablets and sublingual route have been widely used for providing quick onset of action with the avoidance of first pass metabolism. The objective of this work was to compare the effect of different meltable binders namely;…
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Safe excipient exposure in neonates and small children – protocol for the SEEN project.
07. February 2017
INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners…
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Preparation and tableting of long-term stable amorphous rutin using porous silica
17. November 2016
Abstract
Amorphous state of drugs increases the oral bioavailability, but typically faces physical stability problems. Amorphous rutin was generated and physically stabilized by encapsulating inside mesopores of porous AEROPERL® 300 Pharma and named as rutin…
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The effect of a lipid composition and a surfactant on the characteristics of the solid lipid…
Abstract
Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their…
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