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Croda
Preparation, optimization and evaluation of Osthole transdermal therapeutic system
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and…
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Quality by design aided self-nano emulsifying drug delivery systems development for the oral…
The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a quality-by-design (QbD)-based paradigm. Utilizing Labrafil M 2125 CS, Kolliphor EL, and Transcutol P, the…
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ApoE – functionalization of nanoparticles for targeted brain delivery – a feasible…
Abstract
The blood–brain barrier (BBB) poses a major obstacle in the treatment of all types of central nervous system (CNS) diseases. Small interfering RNA (siRNA) offers in principle a promising therapeutic approach by downregulating disease-related genes via RNA interference. However, the BBB is…
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Formulation development and evaluation of fluvastatin loaded transethosomes: Characterization,…
Psoriasis, a common immune-mediated chronic inflammatory disease, may arise from genetic, epigenetic, and immune system factors. Current medications focus on symptom relief, presenting a challenge in discovering new compounds or methods for safe and effective psoriasis management while ensuring…
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Vaccines for a more sustainable future
Climate change is upon us, and we don’t have to look far to find its fallout. Summers are warmer, sea levels are rising and it’s almost impossible to look at the news without encountering a new case of severe weather damage. Heat waves, storms, floods, and wildfires are occurring more often - and…
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Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis…
Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of Idiopathic Pulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to increase their efficacy, which causes significant liver and…
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Topical delivery of nanoemulsions for skin cancer treatment
Skin cancer chemotherapeutics often lead to the development of severe cytotoxicity, compelling the development of novel delivery systems to not only enhance therapeutic efficacy but also minimize side effects and improve patient compliance. In recent years, topical nanoemulsions have emerged as…
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Quality by design (QbD) commended exploration of bosutinib loaded lipid nanocarriers for food effect…
Abstract
Bosutinib (BOS), a BCS class IV drug suffers from poor aqueous solubility and bioavailability along with significant food effect. Lipid nanocarriers (LNC) have the potential to circumvent bioavailability related issues associated with hydrophobic moieties. In this endeavor, we explore the…
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Reversible protein complexes as a promising avenue for the development of high concentration…
Abstract
High concentration formulations have become an important pre-requisite in the development of biological drugs, particularly in the case of subcutaneous administration where limited injection volume negatively affects the administered dose. In this study, we propose to develop high…
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Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded…
Abstract
This study developed a new dual delivery system of naringenin (NRG), a polyphenol, and doxofylline (DOX), a xanthine derivative, as an inhaled microsphere system. In this system, NRG has been first loaded into glyceryl tristearate-based solid lipid nanoparticles (NRG SLN), which were…
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