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Croda
Breaking barriers: Intranasal delivery of brexpiprazole-nanostructured lipid carriers targets the…
With a peak occurrence in mid-teens to early adulthood, schizophrenia is one of the most debilitating illnesses, distinguished by hallucinations, dementia, psychosis, and delirium. According to figures from the World Health Organization, there are 21 million people who have schizophrenia worldwide,…
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Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for…
The anti-inflammatory drug ketoprofen has shown promising results in the field of drug repurposing for the treatment of brain cancer, but currently developed formulations are for invasive administration (intravenous) and have very limited drug strength. Hence, the purpose of this work was to develop…
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Nanostructured lipid carriers loaded into in situ gels for breast cancer local treatment
In this study, nanostructured lipid carriers (NLC) were developed and employed to obtain in situ thermosensitive formulations for the ductal administration and prolonged retention of drugs as a new strategy for breast cancer local treatment. NLC size was influenced by the type and concentration of…
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A new stable and bioactive formulation of Geniotrigona thoracia propolis microemulsion for oral…
Abstract
Propolis, particularly those produced by stingless bees, is known to have a broad range of medicinal benefits due to its antioxidant properties. However, its strong and unpleasant flavour and sticky texture make it less palatable. This study aimed to improve the oral administration of…
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Nanoformulations for dermal delivery of Imiquimod: The race of “soft” against “hard”
Abstract
Imiquimod (IMQ) is an immunostimulating agent used in the treatment of basal cell carcinoma and actinic keratosis. Due to its low solubility and poor skin bioavailability, the dermal formulation of IMQ remains challenging. In analogy to tyre compounds used in Formula 1 racing, we compare…
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Exploring LIPID’s for their Potential to Improves bioavailability of lipophilic drugs candidates: A…
Abstract
This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low…
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Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Abstract
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid…
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Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
D-limonene, derived from citrus essential oils, holds significant therapeutic potential but faces challenges due to its high volatility, especially in pharmaceutical formulations. This study investigates microemulsions as a promising delivery system for volatile compounds, emphasizing their thermal…
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Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with…
This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the oil, Cremophor EL as the surfactant, and Transcutol as the…
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Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally…
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