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Cyclolab
Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability,…
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In…
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Your visit at CPHI worldwide 2022 in Frankfurt
CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
The…
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An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy
Encompassing a group of complex and heterogeneous diseases, cancer continues to be a challenge for patients and healthcare systems worldwide. Thus, it is of vital importance to develop advanced treatment strategies that could reduce the trends of cancer-associated morbidity and mortality rates.…
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Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for…
The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY) to enhance drug delivery and address the aforementioned…
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Cyclodextrin superstructures for drug delivery
Cyclodextrins, typically known for their molecular encapsulation properties to form inclusion complexes with guests of adequate size and hydrophobicity, have recently been explored in tridimensional supramolecular assemblies. These structures have additional advantages over inclusion complexes: they…
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Inhaled Therapy for COVID-19: Considerations of Drugs, Formulations and Devices
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the COVID-19 pandemic, has outspread at full tilt across the world. Although several effective vaccines continue to be deployed, reliable antiviral treatments have yet to be developed against this…
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Based on functional materials and PLGA for the florfenicol controlled release system and its…
It is widely used PLGA in synthesizing active drug nanoparticles due to its high biocompatibility, biodegradability, and pelletization. In this study with PLGA as the carrier, the florfenicol nanoparticles (FF-PLGA NPs) were investigated to improve water solubility and controlled drug release for…
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A Oral Fast Dissolving Films Containing Lyophilized Labetalol HCL with Hydroxy Propyl…
Introduction: Labetalol HCL is an antihypertensive drug used to treat high blood pressure in the long term management of angina. Labetalol HCL is readily absorbed after oral administration. Labetalol HCl undergoes considerable hepatic first-pass metabolism due to its lipid-soluble nature.…
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Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw…
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A different approach to immunochemotherapy for colon Cancer: Development of nanoplexes of…
Immune system deficiencies are crucial in the progression of cancer, predominantly because immune cells are not stimulated by cytokines to eradicate cancer cells. Immunochemotherapy is currently considered an innovative approach that creates pathways in cancer treatment, sometimes also aiding in the…
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