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DFE Pharma
Spherical agglomerates of lactose as potential carriers for inhalation
We report here on spherical lactose agglomerates as potential carriers for inhalation applications. Micromeritic properties of three spherical lactose agglomerates (SA-A, SA-B, SA-C) and a standard lactose inhalation grade carrier (Lactohale 100; LH100) were evaluated and compared. Ordered mixtures…
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Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled…
In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In order to manufacture solid oral dosage forms continuously, valid control strategies for critical quality attributes should be established. To this date,…
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3D Printing in Pharma with Lactose
3D printing brings a whole new dimension to Lactose
Are you ready for the future? 3D Powder bed printing enables to transform the pharmaceutical industry for the better. However only limited expertise on excipient usage in powder bed printing is available. We at DFE pharma also experienced these…
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Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2
Objective(s): Liqui-Mass technology has shown promising advantages in terms of commercial production and formulation manipulation. This study attempts to further explore the potential of enhanced drug release of effervescent Liqui-Pellet by optimizing certain parameters.
Materials and Methods: In…
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Hopper design for piezo-actuated granular flow in powder bed 3D food printing
The flow properties of powders in hoppers are studied in order to make a design procedure for piezo-actuated hoppers that are used to deposit powder layers in multi-material 3D (food) printing. A commercial ring shear tester and an adjustable wedge hopper are used to perform measurements on various…
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Data-smart machine learning methods for predicting composition-dependent Young’s modulus of…
The ability to predict mechanical properties of compacted powder blends of Active Pharmaceutical Ingredients (API) and excipients solely from component properties can reduce the amount of ‘trial-and-error’ involved in formulation design. Machine Learning (ML) can reduce model development time and…
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3D-printing of lopinavir printlets by selective laser sintering and quantification of crystalline…
The objectives of this study were to develop and characterize amorphous lopinavir (LPV) printlets and to the quantify crystalline fraction of LPV in the printlets by X-ray powder diffraction (XRPD)-chemometric models. Amorphous printlets (4.5 mm diameter × 3 mm height) of various LPV concentrations…
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Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing…
Starch is a commonly used excipient in the pharmaceutical industry. However, information on the effect of the moisture scavenging properties of starch to protect moisture-sensitive drugs is limited. The interaction between starch and moisture is of particular interest as moisture fugacity can impact…
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The relevance of granule fragmentation on reduced tabletability of granules from ductile or brittle…
Roll compaction/dry granulation often results in loss of tabletability. The two main hypotheses for this are granule hardening and granule size enlargement. The aim of this study was to investigate the effect of granule size, roll compaction force, and granule fragmentation upon tableting and its…
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Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of orlistat. Based on the in vitro results obtained in this…
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