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DFE Pharma
Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of…
Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to deliver a combination of a fixed dose of two drugs to…
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Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and…
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The Match Between Adhesive Mixture Formulation And Device
The LUND University Sweden, Emmercon and the Swedish Foundation for Strategic Research proudly present the following study:
The Match Between Adhesive Mixture Formulation And Device
INTRODUCTION
This study investigates whether it is the formulation or the device that is key to the…
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Tablet formulation with dual control concept for efficient colonic drug delivery
Aim of this study was to develop a tablet formulation for targeted colonic drug release by implementing two control mechanisms: A pH-sensitive coating layer based on Eudragit® FS 30 D to prevent drug release in the upper gastrointestinal tract, combined with a matrix based on plant-derived…
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Inhaled dry powder cisplatin increases antitumour response to anti-PD1 in a murine lung cancer model
Despite advances in targeted therapies and immunotherapy in lung cancer, chemotherapy remains the backbone of treatment in most patients at different stages of the disease. Inhaled chemotherapy is a promising strategy to target lung tumours and to limit the induced severe systemic toxicities.…
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Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical factors, such as filler (MCC/Mannitol) ratio, mixing time,…
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Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica…
To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a…
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Control Strategy for Excipient Variability in the Quality by Design Approach Using Statistical…
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In this study, the effect of microcrystalline…
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Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet…
Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and, consequently, the quality of final pellets. The most…
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The impact of lactose type on disintegration: An integral study on porosity and polymorphism
Besides factors such as disintegrant and lubricant, the raw material properties of filler excipients can have an impact on the disintegration behavior of a tablet. The current research aims to model the impact of lactose properties on disintegration time. For the first time, the impact of lactose…
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