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Dupont Pharma
Different trends for preparation of budesonide pellets with enhanced dissolution rate
The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In…
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Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release…
The coating is one of the crucial phases in the production of the tablet dosage form with extended-release profiles. Tablet coating has numerous benefits, including disguising the medicine's odor, taste, physicochemical protection, and safeguarding the drug from the stomach environment. The aim to…
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Self-emulsifying drug delivery systems: a novel approach to deliver drugs
Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to…
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Fabrication and Characterization of Orodispersible Composite Film from Hydroxypropylmethyl…
Crosslinked carboxymethyl rice starch (CLCMRS), prepared via dual modifications of native rice starch (NRS) with chloroacetic acid and sodium trimetaphosphate, was employed to facilitate the disintegration of hydroxypropylmethylcellulose (HPMC) orodispersible films (ODFs), with or without the…
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Effect of Moisture of Pharmaceutical Material MCC Avicel PH102 and Tablet Diameter on the…
This paper focuses on the effect of moisture of powder material on the process of tablet compression and on tablet mechanical strength. The powder used in the experiments was Avicel PH102 microcrystalline cellulose, as it is the most widely used excipient in direct tablet compression. The…
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Influence of the Selected Sieving Parameters on the Sieving Efficiency of Material MCC Avicel PH102
Sieving or screening plays a crucial role in the processing of particulate materials. The sieving process is affected by many factors, including the selection of suitable sieving equipment. Several experiments were carried out to examine the influence of three basic sieving parameters on process…
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Predictive modelling of powder compaction for binary mixtures using the finite element method
Despite the widespread use of solid-form drug delivery within the pharmaceutical industry, tablets remain challenging to formulate because their properties depend strongly on the powder composition and details of the compaction process. Powder compaction simulations, using the finite element method…
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Investigation of Quantitative X-ray Microscopy for Assessment of API and Excipient Microstructure…
Assessment and understanding of changes in particle size of active pharmaceutical ingredients (API) and excipients as a function of solid dosage form processing is an important but under-investigated area that can impact drug product quality. In this study, X-ray microscopy (XRM) was investigated as…
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Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM…
Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most frequently employed techniques for 3D printing. The aim of…
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The Effect of Particle Size on The Sublimation of Butylhydroxytoluene in Tablets
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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