Browsing Category
Dupont Pharma
Suspensions and Solutions by IFF Pharma Solutions
Improving patient experience and compliance
Better drug design and delivery options can help improve the likelihood that patients will be more willing to take their medications as prescribed.
Suspensions are defined as finely divided undissolved drugs dispersed in liquid vehicles. They can be a…
Read More...
Read More...
Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential…
At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets. These interactions were observed during an…
Read More...
Read More...
Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible…
Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact with taste buds, taste sensation is an important factor.…
Read More...
Read More...
Using a material database and data fusion method to accelerate the process model development of high…
High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding and controlling this complex process. In this paper, data fusion and multivariate modeling technique were applied to develop a…
Read More...
Read More...
Investigating microcrystalline cellulose crystallinity using Raman spectroscopy
Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity variability can result in downstream process variability. The aim of this study was to develop models to determine…
Read More...
Read More...
3D Printed Intragastric Floating and Sustained-release Tablets with Air Chambers
This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a novel intragastric floating and sustained-release drug delivery system. The intragastric floating and sustained-release tablet was engineered by employing hydroxypropyl…
Read More...
Read More...
Application of SeDeM Expert System in the development of novel directly compressible co-processed…
Background
Computer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for dosage form manufacture. To accelerate development of novel formulations in a quality-by-design perspective, SeDeM Expert System preformulation…
Read More...
Read More...
Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube…
The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method. To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical…
Read More...
Read More...
Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the flows of granular materials are not easy to describe or…
Read More...
Read More...
Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion…
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation of curcumin-loaded mixed micelles of Gelucire® 48/16 and TPGS for its dissolution rate enhancement. Curcumin was dispersed in these molten…
Read More...
Read More...