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Dupont Pharma
Investigation on Hot Melt Extrusion and Prediction on 3D Printability of Pharmaceutical Grade…
The development of printable filaments has been identified as a critical aspect for the processing of pharmaceutical grade polymers and the fabrication of oral solid dosage forms. In this study a range of plain and drug loaded polymers were investigated and assessed for their printability in…
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Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the flows of granular materials are not easy to describe or…
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Screening pharmaceutical excipient powders for use in commercial 3D binder jetting printers
Binder jetting is an additive manufacturing technique that creates three-dimensional constructs from a powder feedstock. It is used by several industries, including pharmaceuticals. This additive approach to manufacture provides several functional benefits that are not easily achievable using…
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Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability…
Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing. The latest advancements include increased use of continuous twin-screw wet granulation and application of…
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Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method…
This study aimed to compare the manufacturability and granule and tablet properties of green fluidized bed granulation (GFBG) and of direct compression (DC). Acetaminophen was used as a low compactabil- ity model drug. The process time of GFBG to produce final mixtures was comparable to that of DC,…
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Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error…
Terahertz time-domain spectroscopy (THz-TDS) is a novel technique which has been applied for pore structure analysis and porosity measurements. For this mainly the anisotropic Bruggeman (AB-EMA) model is applied to correlate the effective refractive index (neff) of a tablet and the porosity as well…
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Vibratory mixing of pharmaceutical powders on a single-tablet-scale
A single-tablet-scale mixing process, being part of a setup for the production of individualized tablets, is developed and studied. The process relies on the principle of vibratory mixing to achieve a homogeneous powder blend in the order of seconds. To investigate the mixing performance under…
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The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous…
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during, and after the fluid bed drying…
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The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy
Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients are dosed simultaneously, the use of minitablets will enable independent adjustments of each dose. The work presented describes the development…
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Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of…
Alginates are biopolymers that have been investigated for their use in food and medical fields. Minimal information is available regarding their potential application as tablet superdisintegrants. Here we studied the disintegration action of sodium alginate (SA), calcium alginate (CA) and alginic…
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