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Dupont Pharma
Innovation and Digital Tools for Better Products and Decision-Making
At the heart of a culture of quality is the desire to continually improve. From the use of digital tools to increase efficiency to innovating a leading brand to tackle tough customer challenges, DuPont continues to enhance the solutions it provides to customers, including the quality of its…
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Polymeric Films Containing Tenoxicam as Prospective Transdermal Drug Delivery Systems: Design and…
The administration of drugs via transdermal therapeutic systems has become an attractive form of therapeutic approach, considering its advantages and the high patient compliance achieved, making them a viable alternative, especially in the treatment of chronic diseases.
The purpose of our study…
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Advancing the Science of TUPs Management: Improved Process Controls, Enhanced Testing Methods and…
Off colored particles, also known as technically unavoidable particles (TUPs) or black specks, have presented challenges for pharmaceutical customers and excipient suppliers for decades. An inherent variability of standard testing and the lack of a common measurement method across the industry…
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Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP…
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Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies
Multiple considerations are essential to address the main challenges of dose flexibility and patient adherence in pediatric drug development, particularly for oncology. Mini-tablets, 2 mm in diameter, were manufactured using a rotary tablet press at a set weight and compression force level. The…
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Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution…
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as…
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Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug…
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Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30 mL/h feeding rate, which is about 30x higher than the…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Permeation and Absorption of Ethanol/Water Mixture through Ethylcellulose Film
Ethylcellulose (EC) is water-insoluble, rate-controlling polymer which has been widely used as coatings of oral solid dosage forms, excipients for amorphous solid dispersions of active pharmaceutical ingredients (APIs), and films for buccal and transdermal drug delivery systems. The interaction of…
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