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Dupont Pharma
Permeation and Absorption of Ethanol/Water Mixture through Ethylcellulose Film
Ethylcellulose (EC) is water-insoluble, rate-controlling polymer which has been widely used as coatings of oral solid dosage forms, excipients for amorphous solid dispersions of active pharmaceutical ingredients (APIs), and films for buccal and transdermal drug delivery systems. The interaction of…
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Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
Purpose
Drug X is high solubility, high permeability BCS/DCS I small molecule drug.
High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam
The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing microcrystalline cellulose, lactose monohydrate, and…
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Evaluation on Biorelevant Dissolution Behavior of Propranolol HCl Encapsulated in Various Capsules
Two-piece hard capsules continuously serve as widely used oral drug and dietary supplement dosage forms. Hard gelatin capsules are used in 20% of all oral dosage forms but have numerous shortcomings especially with potential crosslinking with the active ingredient, the growing consumer preference…
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Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2
Objective(s): Liqui-Mass technology has shown promising advantages in terms of commercial production and formulation manipulation. This study attempts to further explore the potential of enhanced drug release of effervescent Liqui-Pellet by optimizing certain parameters.
Materials and Methods: In…
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DuPont Brings Science-backed Quality and Innovation to Asia’s Pharmaceutical Industry at CPhI China…
The pharmaceutical excipient powerhouse will highlight advancements in controlled release and pediatric medicine in addition to efforts to tackle other prevalent industry issues
SHANGHAI, China, Dec. 01, 2020 – DuPont Nutrition & Biosciences (DuPont) will use insights to help manufacturers…
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Towards functional characterization of excipients for oral solid dosage forms using UV-Vis imaging.…
The purpose of this study was to investigate whole-dosage form UV-Vis imaging as a potential tool for functional characterization of excipients used in solid oral dosage forms. To this end, tablets (average mass 260.0 mg, 224.5 mg and 222.1 mg) containing theophylline anhydrate (20% w/w), 1% (w/w)…
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Self-Nanoemulsifying System Loaded with Sildenafil Citrate and Incorporated within Oral Lyophilized…
Sildenafil citrate is a drug used throughout the world primarily to treat erectile dysfunction. Several problems with the commercially available product decrease its efficacy, such as limited solubility, delayed onset of action, and low bioavailability with a large variability in the absorption…
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Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug…
Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are commonly incorporated into tablets. Disintegration and drug release from ASD tablets are thus critical for achieving…
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Data-smart machine learning methods for predicting composition-dependent Young’s modulus of…
The ability to predict mechanical properties of compacted powder blends of Active Pharmaceutical Ingredients (API) and excipients solely from component properties can reduce the amount of ‘trial-and-error’ involved in formulation design. Machine Learning (ML) can reduce model development time and…
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