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Dupont Pharma
METHOCEL™ Cellulose Ethers – versatile excipients in continuous production and many other…
Did you know that the METHOCEL™ products have been in continuous production for more than 70 years with facilities and deep polymer expertise from our experts located around the globe. Find out more about what this polymer delivers in pharma applications.
METHOCEL™ cellulose ethers are…
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Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability…
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Continuous twin screw granulation: Robustness of lactose/MCC-based formulations
In recent years, significant progress has been made in the field of continuous twin screw granulation. However, only limited knowledge is currently available on the impact of active pharmaceutical ingredient (API) properties on granule quality and processability. In this study, the response behavior…
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In-situ forming implants for dual controlled release of chlorhexidine and ibuprofen for…
In-situ forming implants (ISFI) which simultaneously release an antimicrobial and anti-inflammatory drug in a controlled manner offer an interesting potential for local periodontitis treatment. In this study, poly(lactic-co-glycolic acid) (PLGA)-based implants loaded with chlorhexidine and ibuprofen…
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Accelerated Aqueous Solubility and Antibacterial Activity of Cefuroxime Axetil Using…
This investigation was undertaken to enhance the solubility and consequent antibacterial activity of cefuroxime axetil (CA), a β-lactamase-stable broad spectrum second generation cephalosporin through solid dispersion (SD) technique. For this purpose, CA loaded SDs (CSDs) were prepared by solvent…
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Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic…
The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40…
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Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro…
The improvement of drug solubility is a challenging task in the pharmaceutical industry; moreover, drug stability is also important. This study was designed to improve the dissolution (%) and in vitro anti-inflammation effects of piroxicam (PRX) and maintain its stability using a ternary solid…
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Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria
A model anaerobic bacterium strain from the gut microbiome (Clostridium butyricum) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up nanotechnology, high-speed electrospinning. A long-term…
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Evaluation of an external lubrication system implemented in a compaction simulator
The internal blending of magnesium stearate is often associated with decreasing tensile strengths and longer disintegration and dissolution times. Therefore, external lubrication has gained interest in the pharmaceutical industry as these negative effects could be minimized using this method. In…
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Hot-Melt Extrusion – Enabling Technologies from Dupont
"Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage…
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