Dupont Pharma

AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization. More sophisticated drug discovery techniques have led to pipeline compounds that require…
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Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to develop the nanostructured lipid carriers (NLC) using glyceryl…
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Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. The objective of this study was to predict the effect of formulation on the dissolution rate of a…
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The uniformity of active pharmaceutical ingredient (API) is a main challenge associated with manufacturing low dose tablets. Here, we present a binder enhanced API-microcrystalline cellulose (BEAM) approach to address this challenge. In the BEAM approach a powder is prepared by spraying a PVP…
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Many new chemical entities that are getting developed are poorly aqueous soluble and have low bioavailability. Out of many methods available for improving solubility, the solid dispersion by melt extrusion (ME) and spray drying (SP) is scalable and industrially applicable methods. Objective: The…
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Essential minerals play a very important role in maintaining our physical well-being. In this work, essential minerals; copper sulphate, zinc sulphate, selenium dioxide, chromium picolinate, sodium molybdate and potassium iodide were prepared into tablet formulation with enhanced stability. These…
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Recent work showed that contrary to conventional wisdom, fine surface engineered excipients outperform their larger counterparts in blends of highly loaded blends of cohesive drug powders in terms of their packing, flowability and tablet tensile strength. Here, two continuous devices, fluid-energy…
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The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing…
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Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great variability…
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Co-processed excipients (CPEs) provide functional synergy with the convenience of reduced testing and scale-up. When manufactured under tightly controlled conditions, CPEs deliver consistent, cost-effective performance and are particularly suited for supporting Quality by Design and continuous…
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