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Dupont Pharma
Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable…
In current study, it was investigated if the moisture-mediated polymorphic transition from δ- to β-mannitol during twin screw granulation (TSG) also took place in high drug loaded formulations and if the specific granule morphology associated with the polymorphic transition could enable tableting of…
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Superior Lubrication Performance of Sodium Stearyl Fumarate (Alubra®) in Direct Compression and…
Lubricants are agents added in small quantities to tablet and capsule formulations to improve certain processing characteristics such as decreasing friction, preventing adherence and improving flowability. For the last many decades, the process of lubrication is considered sensitive to overmixing…
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Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has a considerable potential for…
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Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid…
Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it difficult to formulate as an amorphous solid dispersion (ASD) with conventional technologies. KinetiSol® is a high-energy, fusion-based, solvent-free technology that can…
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Oral tablet formulations containing cyclodextrin complexes of poorly water soluble cefdinir to…
Cefdinir (CFD) is an oral cephalosporin antibiotic commonly used in the treatment of community-acquired infections. The oral bioavailability of CFD is limited due to its poor aqueous solubility. Cyclodextrins (CyDs) and their chemically modified derivatives are used in the pharmaceutical field to…
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Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid…
Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced approach that can address low oral bioavailability issues. The antihypertensive drug, nebivolol (NBH), has low bioavailability, about 12%, due to its poor solubility and extensive pre-systematic metabolism. This work aimed to convert…
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Development of an Orodispersible Film Containing Stabilized Influenza Vaccine
Most influenza vaccines are administered via injection, which is considered as userunfriendly. Vaccination via oral cavity using an orodispersible film (ODF) might be a promising alternative. To maintain the antigenicity of the vaccine during preparation and subsequent storage of these ODFs, sugars…
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INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by binder attributes. These critical attributes need to be…
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Towards a molecular understanding of the impact of crystal size and shape on punch sticking
Punch sticking during tablet manufacturing is a common problem facing the pharmaceutical industry. Using several model compounds, effects of crystal size and shape of active pharmaceutical ingredients (API) on punch sticking propensity were systematically investigated in this work to provide…
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Continuous twin screw granulation: A complex interplay between formulation properties, process…
Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly gaining importance in pharmaceutical production. Since a large knowledge gap on the importance of formulation variables exists, this study systematically…
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