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Dupont Pharma
Continuous twin screw granulation: A complex interplay between formulation properties, process…
Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly gaining importance in pharmaceutical production. Since a large knowledge gap on the importance of formulation variables exists, this study systematically…
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Roller compaction: Infrared thermography as a PAT for monitoring powder flow from feeding to…
Roller compaction is a continuous dry granulation process, in which powder is compressed by two counter-rotating rollers. During this process, the powder feeding to the compaction zone has a significant effect on product quality. This work investigates the flow of powder from the feeding zone to the…
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A systematic evaluation of poloxamers as tablet lubricants
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution.
In this…
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Co-processed excipients for direct compression of tablets
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related…
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Investigation of the effects of particle size on fragmentation during tableting
Particle size is a critical parameter during tablet production as it can impact tabletability, flowability, and dissolution rate of the final product.
The purpose of this study was to investigate the effect of initial particle size on fragmentation of pharmaceutical materials during tableting.…
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Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
This review is an extensive evaluation and essential analysis of the design and formation of hydrogels (HGs) for drug delivery.
We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis routes, different types, etc.) that influence their…
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Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
This review is an extensive evaluation and essential analysis of the design and formation of
hydrogels (HGs) for drug delivery. We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis routes, different types, etc.) that influence their…
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Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a…
In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional formulas.
A colon-specific osmotic pump capsule (COPC) of…
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Novel Surfactant Excipient Significantly Improves Biologic Stability in Liquid Formulation
As you maybe aware, polysorbates present a host of challenges for stabilizing biopharmaceuticals due to their own stability issues. To adress this, DuPont Pharma Solutions developed a new surfactant, an experimental material called FM1000!
WATCH THE VIDEO HERE TO GET INFORMED!
Joshua…
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Self-Micellizing Technology Improves the Properties of Ezetimibe and Increases Its Effect on…
The aim of this work was to develop ezetimibe self-micellizing solid dispersions using Kolliphor® RH40 (MS-K) as a surfactant incorporating ezetimibe (EZ) into the croscarmellose hydrophilic carrier.
Different ezetimibe:Kolliphor® ratios were studied to select micellar systems that improve the…
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