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Dupont Pharma
Towards the Continuous Manufacturing of Liquisolid Tablets Containing Simethicone and Loperamide…
Abstract
Continuous manufacturing is becoming the new technological standard in the pharmaceutical industry. In this work, a twin-screw processor was employed for the continuous production of liquisolid tablets containing either simethicone or a combination of simethicone with loperamide…
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Formulation development, optimization, in vivo antidiabetic effect and acute toxicity of directly…
The aim of the present study was to design and optimize the oral tablet formulation of Merremia tridentata extract (MSE) with maximum therapeutic effect and acceptable tablet parameters to aid in diabetes treatment using the response surface methodology (RSM) in the direct compression process. The…
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Assessment of blend uniformity in a stream sampler device using Raman spectroscopy
This study describes the first implementation of Raman spectrometer in a stream sampler for the in-line monitoring of low drug concentration in poor flowability powder blends. Raman spectra were continuously acquired as the powder blends flowed through the stream sampler operating with a paddle…
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Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via…
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size distributions (PSD) in real-time. This model was…
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The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials
A model of the compaction process that has come into increasing use with the pharmaceutical industry is the Drucker-Prager Cap model (DPC). It has long been used in conjunction with the finite element methods to simulate the density and stress distributions in compacts. More recently the calibrated…
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Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials…
Understanding powder flow in the pharmaceutical industry facilitates the development of robust production routes and effective manufacturing processes. In pharmaceutical manufacturing, machine learning (ML) models have the potential to enable rapid decision-making and minimise the time and material…
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Statistical Investigation of Rotary Fluidized Bed Agglomeration Process with Tangential Spray and…
A statistical design of experiments for a rotary fluidized bed agglomeration process is performed to improve both the knowledge of the process and the influence of the process parameters. Agglomerates of a pharmaceutical formulation are manufactured in a laboratory fluidized bed rotor apparatus with…
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Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by…
Hot-melt extrusion (HME) is a technology increasingly common for the commercial production of pharmaceutical amorphous solid dispersions (ASDs), especially for poorly water-soluble active pharmaceutical ingredients (APIs). However, recrystallization of the APIs during dissolution must be prevented…
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Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
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Investigation of the degradation and in-situ amorphization of the enantiomeric drug escitalopram…
Hot-melt extrusion (HME) and subsequent FDM 3D printing offer great potential opportunities in the formulation development and production of customized oral dosage forms with poorly soluble drugs. However, thermal stress within these processes can be challenging for thermo-sensitive drugs. In this…
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