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Dupont Pharma
Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of…
The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and optimization of sildenafil ODMTs as a new dosage form…
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Investigating the Influence of HPMC K4M and Eudragit L 100-55 on Guanfacine-Loaded Extended-Release…
This study aims to optimize the concentrations of hydroxypropyl methyl cellulose (HPMC) K4M and Eudragit L100- 55 (methacrylic acid) in formulation of extended-release tablets containing guanfacine hydrochloride by employing a 32 -factorial design approach. Extended-release tablets of guanfacine…
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Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized…
Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption. Therefore, it is assumed that probiotics protecting animals may…
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Compaction Behavior of Co-Amorphous Systems
Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems. The aim of this study is to investigate the compaction properties of…
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Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride
Antibiotic resistance is one of the most serious health problems today and is expected to worsen in the coming decades. It has been suggested that antibiotic administration routes that bypass the human gut could potentially tackle this problem. In this work, an antibiotic hydrogel-forming microarray…
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Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
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Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs.…
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Flowability, binding and release property of “self-lubricating” microcrystalline cellulose
Microcrystalline cellulose (MCC) has been widely used as an excipient in tablets. Silicified microcrystalline cellulose (SMCC) has more application than MCC by using silicon dioxide (SiO2) as a lubricant. However, findings show that the silicon dioxide (SiO2) nanoparticle component is a…
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Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from…
Fibre-based oral drug delivery systems are an attractive approach to addressing low drug solubility, although clear strategies for incorporating such systems into viable dosage forms have not yet been demonstrated. The present study extends our previous work on drug-loaded sucrose microfibres…
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Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
Objective
The aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct compression method with dual compression.
Methods
In the bilayer system, the immediate release layer was formulated using four types of disintegrants, sodium…
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