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Evonik
Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride…
Abstract
Purpose
Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical…
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Uncovering advances in final end-user applications, user acceptability, quality assurance, and…
The increasing demand for innovative drugs and personalized treatment is radically changing the pharmaceutical industry, where significant efforts in research and development (R&D) are taking place. Three-dimensional (3D) printing offers interesting solutions for these demands, solving some of…
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Preparation, Characterization and Stability Study of Eugenol-Loaded Eudragit RS100 Nanocapsules for…
Eugenol is a phenolic compound with numerous biological activities. It is widely used in dentistry to treat toothache and pulpitis. In particular, eugenol may be used for tooth whitening procedures to minimize dental sensitivity in patients. However, eugenol has some disadvantages such as its…
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3D printing of carvedilol oral dosage forms using selective laser sintering technique
Introduction
The adjustment of the dose according to the individual needs of the patient is a unique advantage of 3D printing technology, which is of particular importance for the pediatric and geriatric population, due to the diverse needs and characteristics of these groups of patients (Kotta et…
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Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide…
Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of formulations capable of delivering the drug to the intestinal…
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3D printed pH-responsive tablets containing N-acetylglucosamine-loaded methylcellulose hydrogel for…
The pH-responsive drug release approach in combination with three-dimensional (3D) printing for colon-specific oral drug administration can address the limitations of current treatments such as orally administered solid tablets. Such existing treatments fail to effectively deliver the right drug…
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Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads Using Box–Behnken Design…
Purpose
The main objective was to develop and optimize a multiparticulate system of 5-fluorouracil through the Box–Behnken design (BBD) and desirability function and coating of the optimized batch for increased therapeutic efficacy and targeting for the treatment of colorectal cancer.
Method
It…
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Design, development, and evaluation of spray dried flurbiprofen loaded sustained release polymeric…
Spray-dried Flurbiprofen (FLB) loaded polymeric nanoformulation using Eudragit L 100 and Ethylcellulose. They were optimized and evaluated. This study determined drug release (%) and encapsulation efficiency (%) by developing a nanoparticulate system using the design of experiment (DoE) approach.…
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Preparation of core-shell controlled release tablets using direct powder extrusion 3D printing…
Three-dimensional printing (3DP) is a widely used technique to manufacture drug delivery systems due to its precision, efficiency, and tailored prescription capability. Although fused deposition modeling (FDM) is the most commonly used technique in the pharmaceutical sciences, there are several…
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Quality-by-Design-Based Development of Rivaroxaban-Loaded Liquisolid Compact Tablets with Improved…
Rivaroxaban (RXN) finds use in the management of pulmonary embolism and deep vein thrombosis. Its poor solubility (5–7 µg/mL) and P-gp-mediated efflux from intestinal lining limits the oral application of RXN. This work assessed the impact of liquisolid compact technique in augmenting the solubility…
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