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Evonik
Quality-by-Design-Based Development of Rivaroxaban-Loaded Liquisolid Compact Tablets with Improved…
Rivaroxaban (RXN) finds use in the management of pulmonary embolism and deep vein thrombosis. Its poor solubility (5–7 µg/mL) and P-gp-mediated efflux from intestinal lining limits the oral application of RXN. This work assessed the impact of liquisolid compact technique in augmenting the solubility…
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Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed excipient properties. The tablet press was equipped with a…
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Advanced process automation of a pharmaceutical continuous wet granulation line: Perspectives on the…
Abstract
Pharmaceutical continuous manufacturing provides the appropriate tools (e.g. the understanding of process dynamics and appropriate and adaptable control strategy) in order to deal with Quality-by-Design expectations and even to the future smart manufacturing described by…
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Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative…
Purpose
The oral administration of drugs is usually the most convenient, economical, and preferred route for patients. Chitosan is a natural polymer that is biocompatible and possesses good mucoadhesion properties and has been proposed for various biomedical applications such as scaffolds in tissue…
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Enteric protection followed by rapid drug release in the upper small intestine or colon
AN ADVANCED PORTFOLIO FOR PRECISE TARGETING AND RAPID DRUG RELEASE
Many oral products require enteric protection followed by rapid, homogeneous drug release to enable precise targeting within either the proximal region of the small intestine or the ileocolonic region. As a leader for…
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Screening and optimization of supercritical fluid process for the preparation of albendazole solid…
Solid dispersion (SD) technology has been proved to be one of the most successful techniques to enhance aqueous solubility of poorly-water soluble drugs. Supercritical fluid (SCF) using carbon dioxide (CO2) became attractive due to its own advantages, including non-toxic, low temperature required,…
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Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition…
Introduction
Cannabidiol (CBD) is a promising non-psychoactive cannabinoid that shows several clinical outcomes. Commercially, this molecule is used in Epidiolex® (Greenwich Biosciences, Inc), a Food and Drug Administration (FDA)-approved drug to treat Lennox-Gastaut and Dravet syndromes,…
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The balance of physical stability and drug release in ternary fenofibrate/HPC/Eudragit L100-55…
Introduction
Amorphous solid dispersions are state-of the art enabling technique for poorly water soluble active pharmaceutical ingredients (APIs). In an ASD, the API is molecularly dissolved in a suitable polymer matrix that stabilizes the amorphous state during storage against recrystallization…
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Pellets and gummies: Seeking a 3D printed gastro-resistant omeprazole dosage for paediatric…
The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of customised medications in small batches. This is particularly helpful for patients who need specific doses or formulations, such as children. Compounding pharmacies seek alternatives to…
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Advances in the Development of Amorphous Solid Dispersions: the Role of Polymeric Carriers
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level. To prepare the solid dispersions, there are many polymers with various…
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