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Evonik
Selective Laser Sintering for printing pharmaceutical dosage forms
Abstract
Three-dimensional (3D) printing has revolutionised the field of pharmaceutical manufacturing due to the unique capabilities to tailor the dosage forms properties and overcome constrains of conventional technologies. There is a plurality of 3D printing techniques that offer flexibility on…
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Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and…
Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products…
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Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight…
Abstract
Aim
The aim of this study was the development and in vivo evaluation of different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH).
Methods
Nanoemulsions (NE) were developed consisting of mainly non-digestible components and variations of polyglycerol-,…
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Novel Bioequivalent Tablet of Solifenacin Succinate Prepared Using Direct Compression Technique for…
Abstract
We designed a bioequivalent tablet form of solifenacin succinate (SOL) with an improved storage stability using a direct compression (DC) technique. An optimal direct compressed tablet (DCT) containing an active substance (10 mg), lactose monohydrate, and silicified microcrystalline…
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Enteric coating of tablets containing an amorphous solid dispersion of an enteric polymer and a…
Recent work has highlighted that amorphous solid dispersions (ASDs) containing delamanid (DLM) and an enteric polymer, hypromellose phthalate (HPMCP), appear to be susceptible to crystallization during immersion in simulated gastric fluids. The goal of this study was to minimize contact of the ASD…
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Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a…
Itraconazole (ITZ), a broad-spectrum antifungal drug, was formulated into colon-targeting system aiming to treat opportunistic colonic fungal infections that commonly infect chronic inflammatory bowel diseases (IBD) patients due to immunosuppressive therapy. Antisolvent precipitation technique was…
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New insights on the effects of blend composition on the biodegradation and permeability of…
Abstract
Inulin has been applied in Inulin-Eudragit RS (Inu-ERS) coatings as the component responsible for degradation by human microbiota. However, studies on how bacterial enzymes can degrade polysaccharides like inulin imbedded in water insoluble polymers like Eudragit RS are still elusive. The…
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Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO…
The current study aimed at optimizing a previously developed non-clinical formulation for use in zolpidem deprescribing. The formulation under investigation consists of extruded zolpidem hemitartrate (30% w/w) and Eudragit EPO (70% w/w) mixtures which display unsatisfactory dissolution behaviour.…
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Eudragit® FS Microparticles Containing Bacteriophages, Prepared by Spray-Drying for Oral…
Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
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Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for…
Layer-by-layer (LbL) modification is an effective way to tune the properties of particles. However, the traditional LbL process involves repeated washing steps which are not compatible with nanoparticles with a partial solubility. In this work, we demonstrate the use of a titration method for…
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