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Evonik
Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles
In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for…
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Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by…
Hot-melt extrusion (HME) is a technology increasingly common for the commercial production of pharmaceutical amorphous solid dispersions (ASDs), especially for poorly water-soluble active pharmaceutical ingredients (APIs). However, recrystallization of the APIs during dissolution must be prevented…
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Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and…
Understanding and controlling the drug solubilization in digestive environment is of great importance in the design of lipid based solid dispersion (LBSD) for oral delivery of poorly aqueous soluble drugs. In the current study we determined the extent of drug solubilization and supersaturation of…
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The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of…
The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments,…
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Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation…
Sorafenib, marketed under the brand name Nexavar®, is a multiple tyrosine kinase inhibitor drug that has been actively used in the clinical setting for the treatment of several cancers. However, the low solubility and bioavailability of sorafenib constitute a significant barrier to achieving a good…
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Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed excipient properties. The tablet press was equipped with a…
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Start of construction of new U.S. facility for pharmaceutical lipids – Evonik Press Release
Press Release, Health Care, Essen, Germany, March 29, 2023
Facility to secure global supply of functional excipients for RNA medicines
Cooperative agreement with U.S. Government to advance U.S. biopharma industry and ensure pandemic preparedness
Start of production scheduled for 2025…
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Manipulating drug release from 3D printed dual-drug loaded polypills using challenging polymer…
Combining multiple medications in a single dosage form has emerged as an important strategy for treating complex diseases and could help tackle the growing issue of polypharmacy. In this study we investigated the suitability of different dual-drug designs for achieving simultaneous, delayed and…
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Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination…
This research aims to develop a drug delivery system that effectively treats colitis while administering curcumin/mesalamine by coating alginate/chitosan beads with Eudragit® S-100 to target the colon. Beads were tested to determine their physicochemical characteristics. Coating with Eudragit® S-100…
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Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
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