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Evonik
3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and…
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms…
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Investigation of the degradation and in-situ amorphization of the enantiomeric drug escitalopram…
Hot-melt extrusion (HME) and subsequent FDM 3D printing offer great potential opportunities in the formulation development and production of customized oral dosage forms with poorly soluble drugs. However, thermal stress within these processes can be challenging for thermo-sensitive drugs. In this…
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Antisolvent Eudragit® polymers based in situ forming gel for periodontal controlled drug delivery
In situ forming gel (ISG) is relevant for periodontal pocket drug delivery because of its local administration with sustained drug release. Various types of 25% w/w Eudragit®-based ISG in different solvents were prepared for 5% w/w doxycycline hyclate (DH) loading. All Eudragit® types could be…
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Moisture sorption by polymeric excipients commonly used in amorphous solid dispersions and its…
Moisture sorption by polymeric carriers used in amorphous solid dispersion (ASD) plays a critical role in the physical stability of the dispersed drug as it can increase molecular mobility of drug in ASD by decreasing the glass transition temperatures (Tg) of the drug-polymer system, leading to drug…
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Investigating the Influence of HPMC K4M and Eudragit L 100-55 on Guanfacine-Loaded Extended-Release…
This study aims to optimize the concentrations of hydroxypropyl methyl cellulose (HPMC) K4M and Eudragit L100- 55 (methacrylic acid) in formulation of extended-release tablets containing guanfacine hydrochloride by employing a 32 -factorial design approach. Extended-release tablets of guanfacine…
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Evonik opens new facility for pharmaceutical lipids at site in Hanau, Germany
PRESS RELEASE
Essen, Germany, March 8, 2023
New GMP facility for clinical and small-scale commercial pharmaceutical lipids
Supports all types of custom and proprietary lipids
Reinforces Evonik’s position as integrated solutions provider for RNA and nucleic acid therapies
Evonik is…
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SIPERNAT®, ZEOFREE® and AEROSIL® for Spray Drying Operations – Technical information by Evonik
Introduction
Spray drying is a common process to isolate solid products from emulsions, dispersions or solutions.
A wide range of products are produced by spray drying:
Food products
(e.g., tomato powder, soup mixes, flavors,
non-dairy creamer, egg powder)
Milk and Dairy products…
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Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
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AEROPERL® 300 Pharma – Improving the dissolution of poorly soluble APIs
AEROPERL® 300 Pharma colloidal silicon dioxide: Our solution to the solubility challenge
Active pharmaceutical ingredients (APIs) by Evonik in oral dosage forms need to dissolve before they can be absorbed in the intestine to enter the systemic circulation. Therefore, both the dissolution of…
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Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a…
The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink…
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