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Evonik
Preparation of nanodelivery systems for oral administration of low molecular weight heparin
Low molecular weight heparins (LMWHs) are only used parenterally. They have low oral absorption and bioavailability due to their high anionic charge density, exposure to enzymatic degradation and first pass effect. The aim of this study was the development and evaluation of nanodelivery systems to…
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Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed…
Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations (printlets) loaded with a narrow therapeutic index drug…
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Tablet formulation with dual control concept for efficient colonic drug delivery
Aim of this study was to develop a tablet formulation for targeted colonic drug release by implementing two control mechanisms: A pH-sensitive coating layer based on Eudragit® FS 30 D to prevent drug release in the upper gastrointestinal tract, combined with a matrix based on plant-derived…
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Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young…
It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases…
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Co-carrier-based solid dispersion of celecoxib improves dissolution rate and oral bioavailability in…
This study aimed to prepare a co-carrier-based solid dispersion (SD) of celecoxib (CXB) to improve its dissolution and oral bioavailability. The CXB-loaded SD formulation was prepared using CXB, pol407, Aerosil 200, and Eudragit L100 at a weight ratio of 1:3:1.5:1. PXRD, DSC, and FTIR analyses were…
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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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Evonik launches plant-based squalene to boost vaccine efficacy – Press Release
PRESS RELEASE
Essen, Germany, December 6, 2022
Evonik has launched a non-animal-derived squalene suitable for vaccines and other pharmaceutical applications. PhytoSquene® is the first known amaranth oil-derived squalene on the market for use in adjuvants in parenteral dosage forms. It meets…
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5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid…
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC) owing to its potent anticancer effects. However, severe systemic side effects and poor drug accumulation in the CRC tissues limit its efficacy. This study aimed to develop 5-FU crystal-incorporated,…
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Extrusion 3D printing of minicaplets for evaluating in vitro & in vivo praziquantel delivery…
This study aimed to explore extrusion three dimensional (3D) printing technology to develop praziquantel (PZQ)-loaded minicaplets and evaluate their in vitro and in vivo delivery capabilities. PZQ-loaded minicaplets were 3D printed using a fused deposition modelling (FDM) principle-based extrusion…
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Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a…
The purpose of this study was to develop an oral paediatric formulation of budesonide (BUD) for the treatment of inflammatory bowel disease. A formulation realized as microspheres using the prilling/vibration technique is proposed as an innovative drug delivery system ensuring BUD-specific colonic…
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