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Evonik
The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug…
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Evonik now offers enteric protected ready to fill capsules EUDRACAP® in IPEC-GMP quality
Highlights
EUDRACAP® functional, ready-to-fill capsules now available for human clinical trials
Supports development and commercialization of complex oral drugs using sensitive molecules, including biologicals
Expands System Solutions based on technology platform for oral advanced…
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Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound…
The acidic pH of healthy skin changes during wound healing due to the exposure of the inner dermal and subcutaneous tissue and due to the potential colonization of pathogenic bacteria. In chronic non-healing wounds, the pH values vary in a wide pH range but the appearance of an alkaline shift is…
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Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization,…
Esomeprazole magnesium (EMP) is a proton pump inhibitor (PPI) that reduces acid secretion. EMP has a short plasma half-life (approximately 1.3 h); hence, nocturnal acid breakthrough (NAB) frequently occurs, disturbing the patient’s nighttime comfort and sleep. We aimed to develop a novel…
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Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In…
The employment of site-specific administration in colon is a promising technique to improve efficacy and reduce systemic side effects of anticancer medications used in colorectal cancer. However, the physiology of the gastrointestinal tract and colonic environment limit the efficient delivery of…
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Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis
Rheumatoid arthritis is a chronic autoimmune disease, with the features of recurrent chronic inflammation of synovial tissue, destruction of cartilage, and bone erosion, which further affects joints tissue, organs, and systems, and eventually leads to irreversible joint deformities and body…
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Manufacture of Tablets with Structurally-Controlled Drug Release using Rapid Tooling Injection…
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are in high demand. One of the main drivers towards micro-scale batch production is the ability to fine-tune drug release. This study demonstrates the use of rapid tooling…
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Different trends for preparation of budesonide pellets with enhanced dissolution rate
The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In…
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Bacterial Cellulose – Adaptation of a Nature-Identical Material to the Needs of Advanced…
Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and…
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Fluid properties of various Eudragit® solutions in different solvent systems for periodontal pocket…
Eudragit® are polymethacrylate-based polymers used for pharmaceutical dosage form development especially for sustained drug release devices. Their fluid properties have not been investigated when using organic solvents used in an in situforming gel (ISG) for periodontal drug delivery via injection.…
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