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Evonik
Method Development Technology and Optimisation Studies in Famotidine Pellets: An In Vitro Release
Oral medication administration has long been the most convenient and widely utilized technique of drug administration. Pellets are fine powders or granules of bulk pharmaceuticals and excipients agglomerated together. They are made up of tiny, freeflowing spherical or semi-spherical solid units that…
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Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’…
Electrospinning and wet-spinning have been recognized as two of the most efficient and promising techniques for producing polymeric fibrous constructs for a wide range of applications, including optics, electronics, food industry and biomedical applications. They have gained considerable attention…
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Identification of Critical Factors Influencing the In-Vitro Dissolution of Bicalutamide Tablets…
This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent,…
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Trojan pH-Sensitive Polymer Particles Produced in a Continuous-Flow Capillary Microfluidic Device…
A facile and robust microfluidic method to produce nanoparticle-in-microparticle systems (Trojan systems) is reported as a delivery vector for the oral administration of active pharmaceutical ingredients. The microfluidic system is based on two coaxial capillaries that produce monodisperse…
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Amorphization of Drugs for Transdermal Delivery -a Recent Update
Amorphous solid dispersion is a popular formulation approach for orally administered poorly water-soluble drugs, especially for BCS class II. But oral delivery could not be an automatic choice for some drugs with high first-pass metabolism susceptibility. In such cases, transdermal delivery is…
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Fluid properties and phase transition of antimicrobial eudragit RS/clove oil in situ forming depot
In situ forming depot (ISD) is a liquid drug delivery formulation generating solid depot after injection via a syringe into the body. The 5% w/w doxycycline hyclate (DH)-incorporated poly (ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) (Eudragit RS) ISD systems…
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Systematic evaluations of melt-extruded filament for fused deposition modeling-mediated 3D printing
Aim: The significant critical barrier in the ascension of fused deposition modeling (FDM) into a scalable technology is the lack of defined quality benchmarks for validating filament performance. To avoid this issue, we aimed to create a comprehensive quantitative approach providing a road map to…
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Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on…
The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures (CPs) from 50 to 500 MPa was performed using a compaction…
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Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to…
Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble…
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pH-sensitive liposomes for colonic Co-delivery of mesalazine and curcumin for the treatment of…
The incompetence of the current management of ulcerative colitis (UC) demands novel pharmaceutical techniques and advance therapeutic strategies to facilitate safe and efficacious treatment of the disease. In this quest, mesalazine, a 5-aminosalicylate with anti-inflammatory and potent antioxidant…
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