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Evonik
Comparative Study of Powder Carriers Physical and Structural Properties
High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems…
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Development of mucoadhesive carrier systems for flavoring agents and cannabidiol
The buccal mucosa represents an attractive site to realize both local and systemic effects. It is easily accessible and transbuccal drug delivery offers the opportunity to increase bioavailability of drugs by avoiding first-pass metabolism and intestinal drug degradation. But despite numerous…
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Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low…
Low amounts of minoxidil in oral dosage forms are commonly prescribed as anti-alopecic pharmacological treatments. Side effects are usually related to individual susceptibility. However, poor drug content and mass uniformity can lead to a potential risk of overdosing, and higher chances to…
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Replacing PEG-surfactants in self-emulsifying drug delivery systems: Surfactants with polyhydroxy…
Aim
Evaluation of different polyhydroxy surfaces in SEDDS to overcome the limitations associated with conventional polyethylene glycol (PEG)-based SEDDS surfaces for intracellular drug delivery.
Highlights
Polyethylene glycol- (PEG-) surfactants in self-emulsifying drug delivery…
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Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations
The symptoms of some diseases show circadian rhythms, such as the morning stiffness associated with pain at the time of awakening in rheumatoid arthritis. Therapy for such diseases doesn’t require immediate release or sustained release of medicament. In such therapies, pulsatile drug release is more…
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Evonik launches new EUDRATEC® technology to improve solubility of oral small molecules
Essen, Germany. Evonik now offers EUDRATEC® SoluFlow, a new microparticle technology to enhance solubility of active pharmaceutical ingredients in oral drug products. This emulsion-based process technology overcomes solubility hurdles that cannot be resolved by existing manufacturing technologies.…
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Nanocarrier Systems in Taste Masking
Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the pharmaceutical industry. Numerous conventional taste-masking…
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Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties
To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO)…
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Evonik increases global supply of pharma-grade plant-derived cholesterol for mRNA vaccines and gene…
Extra production capacity for PhytoChol® at German site
Meets increasing demand for critical lipid used in mRNA vaccines, gene therapies and other parenteral applications
Strengthens Evonik’s position as system solutions provider for the pharma and biotech industries
Essen,…
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Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS, and two stabilizers (PVP and PVA) were evaluated for NPs…
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