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Evonik
Influence of commonly used excipients on the chemical degradation of enalapril maleate in its solid…
The physicochemical stability of enalapril maleate was investigated in the presence of fourteen different excipients divided into four different classes. The extent of a drug-excipient interaction was investigated by following the chemical stability using HPLC. It was found that there is a certain…
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Evonik – Now also a global CDMO for lipid nanoparticles
INTEGRATED CDMO SERVICES FOR LIPID-NANOPARTICLE-BASED GENETIC DRUGS AND OTHER NANOMEDICINES SINCE THE 1990S
Evonik Vancouver Laboratories, formerly known as Transferra Nanosciences Inc. or Northern Lipids, has been a market CDMO leader for lipid nanoparticle (LNP)-/liposome-based formulations for…
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Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of…
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We…
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A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can pose the risk of tube clogging. Compared to the…
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A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery…
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic approach was based on first identifying appropriate excipients…
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Eudragit S100 prepared pH-responsive liposomes-loaded betulinic acid against colorectal cancer in…
This study aimed to develop polymer Eudragit S100 for preparing pH-responsive liposomes-loaded betulinic acid (pH-BA-LP) to improve the therapeutic index of chemotherapy for colorectal cancer. BA-loaded liposomes were coated with Eudragit S100 by a thin film dispersion and easily scalable pH-driven…
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Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin…
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Solving Compactability Issues for the Preparation of ODTs
Introduction
Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the best-in-class co-processed excipient for ODT, may work as…
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Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed…
Extrusion-based 3D-printing is an easy-to-use, cheap manufacturing technique that could be used to produce tailored precision medicines. The technique has an almost unlimited versatility since a multitude of print parameters can easily be adapted. Unfortunately, little is known of the effect of…
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Lipid Nanoparticles for Drug Delivery
Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as…
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