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Evonik
Development of a 3D-Printed Dosing Platform to Aid in Zolpidem Withdrawal Therapy
The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching worrying intake rates, and therefore, the need for action is…
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Downstream processing of spray-dried ASD with hypromellose acetate succinate – Roller compaction and…
Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersions with HPMCAS. Poor flow and high dilution factor are a…
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Development of Mucoadhesive Film-Forming Systems Containing Black Ginger Extract for Aphthous Ulcers
Film-forming systems (FFSs) were developed by using Eudragit® E100 as a film former. Kaempferia parviflora (black ginger) extract was used as an anti-inflammatory agent for aphthous ulcers. The FFS could rapidly form a thin film in only 5 s when it was applied to a wet surface e.g. an aphthous…
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Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery
The present study describes the use of two taste-masking polymers to fabricate a formulation of chlorpheniramine maleate for paediatric administration. Co-axial electrospinning was utilized to create layered nanofibres; the two polymers, Eudragit® E PO and Kollicoat® Smartseal, were alternated…
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Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and…
This study aimed to prepare pullulan films containing pomegranate seeds oil (PSO) based nanocapsules, and evaluate the formulation efficacy in the treatment of atopic dermatitis (AD)-like lesions induced by 2,4-dinitrochlorobenzene (DNCB). The Eudragit RS 100® nanocapsules (PSONC) were prepared by…
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Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral…
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologies have the potential to achieve retention of the…
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Impressions from Vitafoods 2021
The time has come! The first live events are starting again, including Vitafoods in Geneva. Unlike usual, Vitafoods is a hybrid event. Participants can decide if they want to participate online only or visit the halls in Geneva as well. Have a look at the booth pictures of some of our partners in…
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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing…
One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,…
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Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically…
The preparation of the metal surface before coating application is fundamental in determining the properties of the coatings, particularly the roughness, adhesion, and corrosion resistance. In this work, chitosan/Eudragit E 100 (chit/EE100) were fabricated by electrophoretic deposition (EPD) and…
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Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration
Alkanediols are widely used as multifunctional ingredients in dermal formulations. In addition to their preservative effect, considering their possible impact on drug penetration is also essential for their use. In the present study, the influence of 2-methyl-2,4-pentanediol, 1,2-pentanediol,…
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