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Evonik
Hierarchical Bayesian approach applied to the formulation of sustained-release suppositories and…
The hierarchical Bayesian modeling approach was used to select the appropriate empirical kinetics model of sustained release and to optimize the in vitro dissolution rate of the sustained-release suppository by controlling the composition of Eudragit L-100 and Eudragit S-100 in the experimental…
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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In this study, various release modifying excipients, namely,…
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Preparation and characterization of Eudragit L 100-55/chitosan enteric nanoparticles containing…
Background and purpose: Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases. The current study aimed to prepare enteric-coated nanoparticles containing OMP to achieve a stable powder formulation easily prescribed in children.
Experimental…
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A Trusted Solutions Provider To Adress Poor Drug Solubility
THE DRUG SOLUBILITY SPECIALIST FOR SOLID DISPERSIONS, PARTICLE ENGINEERING AND SILICA TECHNOLOGIES
Almost half of currently marketed drug products, and around 90 % of those in clinical development are associated with poor drug solubility or permeability. A multitude of factors can affect drug…
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Assessment of a Once-Daily Controlled-Release Ibuprofen Matrix Tablets Prepared Using…
Introduction
Hydrophilic polymers that swell or dissolve in aqueous media can have the potential to prepare controlled/sustained dosage forms for weakly acidic, poorly soluble drugs.
Objective
The main objective of this study is to utilize Eudragit®E100 (EE) and Carbopol®971P NF (Cp) polymers and…
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using…
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the…
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Solubility Enhancement of Diclofenac Using Solid Dispersions
The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low aqueous solubility of 0.00401mg/ml. Amongst various…
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Dual-Acting Zeta-Potential-Changing Micelles for Optimal Mucus Diffusion and Enhanced Cellular…
Context: Overcoming the intestinal mucosal barrier can be a challenge in drug delivery. Nanoemulsions with negative zeta potentials can effectively permeate the mucus layer, but those with positive zeta potentials are better taken up by cells; a nanoemulsion with capricious zeta potential from…
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Segmented intravaginal ring for the combination delivery of hydroxychloroquine and anti-CCR5 siRNA…
Vaginal drug delivery has been shown to be a promising strategy for the prevention of sexually transmitted infections. Therapy delivered at the site of infection has many advantages including improved therapeutic efficacy, reduction in systemic toxicity, and reduced potential for development of drug…
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Mucoadhesive and mucus-penetrating Interpolyelectrolyte complexes for nose-to-brain drug delivery
Nasal administration offers a possibility of delivering drugs to the brain. In the present work, nasal drug delivery systems were designed based on cationic Eudragit® EPO (EPO) and anionic Eudragit® L100–55 (L100–55) methacrylate copolymers. Two types of nanocarriers were prepared using…
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