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Evonik
Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents
In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-triggered release approach has several advantages over other approaches due to unique microbial ecosystem in the colon. Multiple-unit carriers have an edge over single-unit carriers for this purpose. Among…
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Film-Forming Systems for Dermal Drug Delivery
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming…
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Three-dimensional printing of tablets – a potential approach to on-clinical-site extemporaneous…
The oral route is the most common form of drug administration, being a safe and convenient, particularly for solid oral dosage forms. Current large-scale manufacturing techniques mostly result in fixed dose units and allow a limited choice of dosage strengths. In some cases, there is a need for…
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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared…
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however, continuous manufacturing of tablets have not been realized…
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Development and evaluation of a composite dosage form containing desmopressin acetate for buccal…
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and oromucosal, whereby nasal administration results in high…
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3D-printed construct from hybrid suspension as spatially and temporally controlled protein delivery…
Protein delivery systems have been extensively applied in controlled releasing of protein or polypeptides for therapeutic treatment or tissue regeneration. While 3D printing technology shows great promise in novel dosage form with tailoring dose size and drug release profile, 3D printable protein…
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Anti-counterfeiting protection, personalized medicines − development of 2D identification methods…
Counterfeiting of the products for healing is as old as trading, and it is difficult to quantify the magnitude of the problem. It is known that substandard and/or falsified (SF) medicines are a growing global threat to health, and they cause serious social and economic damage. The EU has a strong…
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Formulation and evaluation of sustained release pellets of lornoxicam
Objective: The aim of study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency.
Methods: The sustained release pellets of lornoxicam were prepared by extrusion – spheronization technique using Eudragit RLPO and Eudragit RSPO…
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Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100…
A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a sustained release pattern by covering hydrophilic polymers, chitosan/polyvinyl alcohol (CS/PVA) nanofibers, with a hydrophobic polymer, Eudragit RL100…
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