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Evonik
Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and assess the practicability of its development…
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Developing and evaluation of orodispersible tablets containing caffeine
Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAF- ODTs). The formulation variables were the type of disintegrant…
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The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride…
In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such that temperatures are maintained below melting point of drugs but above glass transition of polymers used, whereby the polymers coat surfaces of drug…
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Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed…
Purpose
Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability.
Methods
A binder jet 3D printer was used to prepare…
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Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of…
This study aimed to improve the dissolution of the poorly soluble drug lopinavir (LPV) by preparing amorphous solid dispersions (ASDs) using solvent evaporation method. The ASD formulations were prepared with ternary mixtures of LPV, Eudragit® E100, and microcrystalline cellulose (MCC) at various…
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Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method…
This study aimed to compare the manufacturability and granule and tablet properties of green fluidized bed granulation (GFBG) and of direct compression (DC). Acetaminophen was used as a low compactabil- ity model drug. The process time of GFBG to produce final mixtures was comparable to that of DC,…
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Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness
The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual…
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Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers
Capsules are a widely used oral dosage form due to their simplicity and ease of manufacture. They are equally popular for both pharmaceutical and nutraceutical products and since they do not need extensive formulation development, it is a dosage form of choice for new drugs undergoing animal or…
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Garcinol Encapsulated Ph-Sensitive Biodegradable Nanoparticles: A Novel Therapeutic Strategy for the…
The emergence of pH-sensitive nanoscale particles is beneficial due to their ability to only release cargo in a colonic pH environment, which helps to directly target inflamed tissues in inflammatory bowel disease (IBD). Hence, we have designed the formulation of pH-sensitive biodegradable garcinol…
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Studies on Formulation and Evaluation of Eudragit RS PO Based Nanoparticulate System of Aceclofenac…
Aim: Ocular drug delivery is the most challenging and interesting goal in front of the pharmaceutical scientist. Ocular inflammation is the most commonly affecting disease of the eye. The objectives of present investigation were to formulate and evaluate eudragit RS PO (ERS PO) based Aceclofenac…
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